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1.
Aliment Pharmacol Ther ; 23(1): 175-84, 2006 Jan 01.
Article in English | MEDLINE | ID: mdl-16393295

ABSTRACT

BACKGROUND: The prevalence of gastro-oesophageal reflux disease (GERD), has not been characterized in Spain. Aim To measure the prevalence of GERD in Spain, and the factors associated with it, by means of a primary care-based study. METHODS: An epidemiological, multicentre, cross-sectional, population-based study. A self-administered questionnaire was sent out to randomly selected patients. Data were statistically analysed to provide the prevalence of GERD and to compare it with that of gastro-oesophageal reflux symptoms. Factors associated with GERD were studied using logistic regression models. RESULTS: The response rate was 45%. The prevalence of GERD was 15% (95% CI: 13.2-16.2). When compared with gastro-oesophageal reflux symptoms patients, those with GERD experienced more intense symptoms (moderate-severe: 35% vs. 8%, P < 0.001) and suffered heartburn more frequently both at day and night (48% vs. 25%, P < 0.001) and for longer period of times (69% vs. 62%, P = 0.057). A body mass index of >25% (odds ratio: 1.07; 95% CI: 1.03-1.11) was the only independent variable associated with GERD. The risk of suffering GERD increases by 7% for each kg/m(2) that the body mass index increases. CONCLUSIONS: The prevalence of GERD among the Spanish population is 15%. Body mass index is the only risk factor significantly associated with GERD.


Subject(s)
Gastroesophageal Reflux/epidemiology , Adult , Aged , Cross-Sectional Studies , Female , Heartburn/epidemiology , Humans , Male , Middle Aged , Prevalence , Risk Factors , Spain/epidemiology , Surveys and Questionnaires
2.
Rev. clín. esp. (Ed. impr.) ; 205(12): 588-594, dic. 2005. tab, graf
Article in Es | IBECS | ID: ibc-043022

ABSTRACT

Introducción. Los síntomas de pirosis y su impacto en la calidad de vida relacionada con la salud (CVRS) son con frecuencia evaluados en los ensayos clínicos. Cuando un cuestionario es traducido a un idioma diferente al que se originó es necesaria una validación lingüística, aunque no es suficiente a menos que hayan sido verificadas las características psicométricas. El objetivo del trabajo es documentar las características psicométricas de la traducción al español de la escala de evaluación de síntomas gastrointestinales (GSRS) y del cuestionario de calidad de vida de reflujo y dispepsia (QOLRAD). Material y método. Ciento cincuenta y ocho pacientes con síntomas de pirosis (edad: 51,0; DE: 16,3 años; varones: 42,4%) completaron la traducción al español de la GSRS, la versión de pirosis del QOLRAD, el Short-Form-36 (SF-36) y la escala hospitalaria de ansiedad y depresión (HAD). Setenta y seis pacientes fueron citados a una segunda visita pasada una semana para completar de nuevo la GSRS y el QOLRAD. Resultados. La fiabilidad de la consistencia interna de la GSRS fue 0,59-0,83 y la del QOLRAD 0,87-0,95, y la fiabilidad del test-retest de la GSRS fue 0,44-0,63 y del QOLRAD 0,77-0,85. La puntuación de los dominios importantes de la GSRS «reflujo», «dolor abdominal» e «indigestión» y todos los del QOLRAD se correlacionaron significativamente. El dominio «dolor abdominal» de la GSRS tuvo una fuerte correlación (negativa) con los dominios relevantes del SF-36. Los dominios del QOLRAD se correlacionaron significativamente con todos los dominios relacionados del SF-36. Conclusiones. Las características psicométricas de la traducción al español de la GSRS y del QOLRAD fueron buenas, con una fiabilidad y validez satisfactorias. Sin embargo, la fiabilidad test-retest del dominio «reflujo» de la GSRS no fue óptima


Introduction. Pyrosis symptoms and their impact on the quality of life related with health (QLRH) are frequently evaluated in clinical trials. When a questionnaire is translated into a language other than the original, it is necessary to have a linguistic validation, although this is not sufficient unless the psychometric characteristics have been verified. This study aims to document the psychometric characteristics of the translation to spanish of the gastrointestinal symptoms rating scale (GSRS) and quality of life in reflux and dyspepsia (QOLRAD). Material and method. One hundred fifty eight patients with pyrosis symptoms (age: 51.0; SD: 16.3 years; men: 42.4%) completed the translation to spanish of the GSRS, the pyrosis version of the QOLRAD, the Short-Form-36 (SF-36) and the hospital of anxiety and depression (HAD) scale. Seventy six patients were given an appointment for a second visit after one week, to fill out the GSRS and QOLRAD again. Results. The reliability of the internal consistence of the GSRS was 0.59-0.83 and that of the QOLRAD: 0.87-0.95, and test-retest reliability of the GSRS was 0.44-0.63 and QOLRAD: 0.77-0.85. Score of the important domains of the GSRS «reflux», «abdominal pain» and «indigestion» and above all those of the QOLRAD correlated significantly. The domain «abdominal pain» of the GSRS had a strong correlation (negative) with the relevant domains of the SF-36. The QOLRAD domains significantly correlated with all the related domains of the SF-36. Conclusions. The psychometric characteristics of the translation to spanish of the GSRS and QOLRAD were good, with satisfactory reliability and validity. However, the test-retest reliability of the «reflux» domain of the GSRS was not optimum


Subject(s)
Adult , Middle Aged , Humans , Dyspepsia/psychology , Gastroesophageal Reflux/psychology , Sickness Impact Profile , Dyspepsia/physiopathology , Gastroesophageal Reflux/physiopathology , Language , Psychometrics , Quality of Life , Spain
3.
Rev Clin Esp ; 205(12): 588-94, 2005 Dec.
Article in Spanish | MEDLINE | ID: mdl-16527180

ABSTRACT

INTRODUCTION: Pyrosis symptoms and their impact on the quality of life related with health (QLRH) are frequently evaluated in clinical trials. When a questionnaire is translated into a language other than the original, it is necessary to have a linguistic validation, although this is not sufficient unless the psychometric characteristics have been verified. This study aims to document the psychometric characteristics of the translation to Spanish of the gastrointestinal symptoms rating scale (GSRS) and quality of life in reflux and dyspepsia (QOLRAD). MATERIAL AND METHOD: One hundred fifty eight patients with pyrosis symptoms (age: 51.0; SD: 16.3 years; men: 42.4%) completed the translation to Spanish of the GSRS, the pyrosis version of the QOLRAD, the Short-Form-36 (SF-36) and the hospital of anxiety and depression (HAD) scale. Seventy six patients were given an appointment for a second visit after one week, to fill out the GSRS and QOLRAD again. RESULTS: The reliability of the internal consistence of the GSRS was 0.59-0.83 and that of the QOLRAD: 0.87-0.95, and test-retest reliability of the GSRS was 0.44-0.63 and QOLRAD: 0.77-0.85. Score of the important domains of the GSRS "reflux", "abdominal pain" and "indigestion" and above all those of the QOLRAD correlated significantly. The domain "abdominal pain" of the GSRS had a strong correlation (negative) with the relevant domains of the SF-36. The QOLRAD domains significantly correlated with all the related domains of the SF-36. CONCLUSIONS: The psychometric characteristics of the translation to Spanish of the GSRS and QOLRAD were good, with satisfactory reliability and validity. However, the test-retest reliability of the "reflux" domain of the GSRS was not optimum.


Subject(s)
Dyspepsia/psychology , Gastroesophageal Reflux/psychology , Sickness Impact Profile , Adult , Dyspepsia/physiopathology , Female , Gastroesophageal Reflux/physiopathology , Humans , Language , Male , Middle Aged , Psychometrics , Quality of Life , Spain
5.
Anticancer Res ; 17(3B): 1619-21, 1997.
Article in English | MEDLINE | ID: mdl-9179205

ABSTRACT

UNLABELLED: The aim of this study is to characterise benign from malignant breast lesions by using 99mTc-Tetrofosmin. MATERIALS: Fifteen female patients with suspected breast lesions and ten normal controls underwent breast scintigraphy with 99mTc-Tetrofosmin. All patients had conventional mammography. Breast imaging begun 20 minutes after i.v. injection of 740 MBq 99mTc-Tetrofosmin. Patients were imaged in supine and prone position. Results of the 15 patients with suspected breast lesions, 13 showed breast uptake, and 6 of them had suspicious lesions on mammography. Surgery confirmed 10 carcinomas and 3 benign lesions. Two patients demonstrated no abnormal accumulation or suspicious findings in mammography. None of the normal controls had breast uptake or mammographic abnormalities. Our study has a sensibility of 100% and 60%, and a specificity of 80% and 100% in scintigraphy and mammography respectively. CONCLUSION: Our findings suggest that 99m Tc-Tetrofosmin may play a role in evaluating breast masses and that can differentiate benign from malignant lesions.


Subject(s)
Breast Diseases/diagnostic imaging , Breast Neoplasms/diagnostic imaging , Organophosphorus Compounds , Organotechnetium Compounds , Adolescent , Adult , Aged , Breast Diseases/pathology , Breast Diseases/surgery , Breast Neoplasms/surgery , Carcinoma/diagnostic imaging , Carcinoma/surgery , Diagnosis, Differential , Female , Gamma Cameras , Humans , Mammography , Middle Aged , Radionuclide Imaging , Radiopharmaceuticals , Sensitivity and Specificity
6.
Surgery ; 121(5): 535-41, 1997 May.
Article in English | MEDLINE | ID: mdl-9142152

ABSTRACT

BACKGROUND: Until now, preoperative parathyroid imaging has been considered unnecessary because currently available techniques do not provide any better results than an expert surgeon. We conducted a multicenter prospective study evaluating the capability of technetium 99m sestamibi scintigraphy in the preoperative identification of pathologic glands. METHODS: Ninety-three patients with hyperparathyroidism, seven of them reoperative cases, were studied. In addition, 20 age-matched normocalcemic control subjects were also studied. RESULTS: Surgical confirmation of scintigraphic images was obtained in 91 of 93 cases (sensitivity, 97.8%). In all reoperative cases (n = 7), in all cases of ectopic glands (whether operated or not; n = 6), and in all patients with a single-gland disease (n = 70), topographic identification of the pathologic gland was correct in 100%. In multiple-gland disease (n = 23), involvement of more than one gland was visualized in only 61% of the patients; however, in 91% of patients, at least one gland was localized. Surgical success-defined as postoperative normocalcemia-with this approach was 100%. All scans of normocalcemic control subjects were negative. Of 31 patients in whom a multinodular goiter coexisted, seven presented a significant radionuclide background at 120 minutes' scan. False-positive images were found together with those corresponding to the pathologic glands in only three cases. CONCLUSIONS: 99mTc-sestamibi is a highly reliable, sensitive, and specific technique for imaging of pathologic glands in hyperparathyroidism, especially in single-gland disease. It may be considered as a first line single-procedure when a preoperative topographic diagnosis is required.


Subject(s)
Hyperparathyroidism/diagnostic imaging , Radiopharmaceuticals , Technetium Tc 99m Sestamibi , Adult , Aged , Female , Humans , Hyperparathyroidism/surgery , Male , Middle Aged , Preoperative Care , Prospective Studies , Radionuclide Imaging , Reproducibility of Results , Sensitivity and Specificity
7.
Eur J Nucl Med ; 23(3): 243-6, 1996 Mar.
Article in English | MEDLINE | ID: mdl-8599954

ABSTRACT

Abdominal scintigraphy with technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO)-labelled leucocytes is an excellent tool for evaluating disease extent and activity of intestinal lesions in patients with inflammatory bowel disease (IBD). In some cases of seronegative spondylarthropathies (SSp), IBD may remain subclinical. The aim of this study was to evaluate the presence of positive abdominal scintigraphy in patients with SSp and without clinical symptoms or signs of IBD. To this end we studied 32 patients with active SSp (European Spondylarthropathy Study Group 1991 criteria) without clinical evidence of IBD (eight had ankylosing spondylitis, four psoriatic arthritis, three reactive arthritis an 17 undifferentiated SSp) and 11 controls without SSp. All SSp and control patients received similar doses of non-steroidal anti-inflammatory drugs (NSAIDs). Abdominal scintigraphic images were obtained at 30 and 120 min after re-injection of 99mTc-HMPAO-labelled leucocytes. The 99mTc-HMPAO-labelled leucocyte scan was positive in 17 patients with SSp (53.1%) (six with ankylosing spondylitis, three with psoriatic arthritis, two with reactive arthritis and six with undifferentiated SSp). Fourteen patients scored from 2 to 4 on the intensity of uptake scale. The colon and terminal ileum were predominantly involved. Axial involvement was more frequent in patients with a positive scan than in patients with negative results (P<0.05) (64.7% vs 26.6%; odds ratio: 5). No control patient showed a positive scan. It is concluded that 99mTc-HMPAO-labelled leucocyte scan shows increased uptake among patients with SSp without evidence of IBD. These findings provide new evidence linking SSp with intestinal inflammation and suggest that in some cases a bowel-related process could contribute to the development of SSp. Long-term follow-up studies with more patients are necessary to evaluate the diagnostic and therapeutic implications of these results.


Subject(s)
Inflammatory Bowel Diseases/diagnostic imaging , Organotechnetium Compounds , Oximes , Spondylitis, Ankylosing/diagnostic imaging , Abdomen/diagnostic imaging , Adult , Female , Humans , Leukocytes/diagnostic imaging , Male , Middle Aged , Radionuclide Imaging , Serologic Tests , Technetium Tc 99m Exametazime
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