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1.
Ann N Y Acad Sci ; 1054: 495-9, 2005.
Article in English | MEDLINE | ID: mdl-16339705

ABSTRACT

Extended antigen (C, E, K) matching decreased the incidence of alloantibody (alloAB) and autoantibody (autoAB) formation, in addition to eliminating transfusion reactions in the multiply transfused sickle cell disease patients. AlloAB formation possibly transforms the immune system into a hyperactive state leading to further and earlier alloAB and autoAB formation. However, additional CEK matching results in marked overuse of Rh-negative packed red blood cell (pRBC) units, 30 minutes' extra time of a skilled technologist, and 153 dollars extra CEK reagent cost per unit to find CEK-matched pRBCs for every transfusion for these multiply transfused patients.


Subject(s)
Anemia, Sickle Cell/immunology , Autoantibodies/blood , Blood Group Antigens/immunology , Erythrocyte Transfusion/adverse effects , Immunization , Isoantibodies/blood , Adolescent , Adult , Aged , Anemia, Sickle Cell/blood , Anemia, Sickle Cell/therapy , Blood Group Incompatibility/immunology , Blood Grouping and Crossmatching , Child , Child, Preschool , Female , Humans , Incidence , Infant , Male , Middle Aged , Retrospective Studies
4.
CAP Today ; 15(1): 6, 8, 2001 Jan.
Article in English | MEDLINE | ID: mdl-11317558
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