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Bioorg Med Chem Lett
; 16(10): 2637-40, 2006 May 15.
Article
in English
| MEDLINE
| ID: mdl-16517160
ABSTRACT
The synthesis of three series of quinol fatty alcohols (QFAs) and their biological activities on the promotion of axonal growth are described. Interestingly, the 15-(2,5-dimethoxyphenyl)pentadecan-1-ol, the QFA bearing 15 carbon atoms on the side chain (n=15), shows the most potent promotion of axonal growth in the presence of both permissive and non-permissive naturally occurring substrates such as Sema3A and myelin proteins.