ABSTRACT
PURPOSE: Incomplete polymerisation processes produce several leachable substances. The aim of this work was to review, through existing research and published literature, the genotoxic effect of residual monomers of polymers used in restorative dentistry. MATERIALS AND METHODS: The selection of published studies was performed on six databases from January 2000 to June 2020. The keywords used were: 'genotoxicity' or 'DNA damage' and 'dental resin' or 'methacrylates' or 'residual monomers'. The selection was carried out according to the parameters and guidelines of the Preferred Reporting Items for Systematic Review and Metanalyses (PRISMA) and was based on patient, intervention, comparison, and outcome (PICO). The inclusion criteria were: in vitro and in vivo studies published in English that evaluated genotoxicity for residual monomers leached from polymers related to restorative dentistry. Case reports and review articles were excluded. RESULTS: Twenty-seven studies met the eligibility criteria. Two categories were constructed based on the experimental design, in vivo and in vitro reports. For the in vitro research, two main methods of assessing DNA damage were reported in selected studies: micronucleus (MN) counting and alkaline comet assay. For in vivo reports, the main method for assessing genotoxic damage was MN counting. CONCLUSION: From the electronic search, structured data extraction, and analysis by different independent reviewers, results from the present systematic review allow us to conclude that DNA damage is induced by monomers/co-monomers (triethylene glycol dimethacrylate, bisphenol-A-glycidyl methacrylate, urethane dimethacrylate, and 2-hydroxyethyl methacrylate) that are used in restorative dentistry. This systematic review highlights the need for more research on the use of monomers/co-monomers to properly assess clinical biocompatibility.
Subject(s)
DNA Damage , Dentistry , Bisphenol A-Glycidyl Methacrylate , Composite Resins , HumansABSTRACT
RESUMEN: La Dimensión Vertical Oclusal, es la distancia entre un punto anatómico fijo en el maxilar y otro sobre la parte móvil de la mandíbula cuando los órganos dentarios están en contacto oclusal. La obtención de este registro determina el espacio vertical necesario para la rehabilitación de los pacientes. En la actualidad existen distintos métodos para el registro de la Dimensión Vertical Oclusal, en este estudio se analizaron: Métodos fisiológicos y métodos mecánicos. El objetivo fue realizar una revisión sistemática, sobre los métodos de registro, para determinar la Dimensión Vertical Oclusal en pacientes dentados. Se recopiló información científica desde Mayo 2019 hasta Julio 2020 en diferentes bases de datos electrónicas, encontrando un tota l de 13948 artículos, después de eliminar artículos repetidos, por título, por resumen y por metodología PICO se seleccionaron un total de 24 artículos para su análisis y clasificación. Más de un autor menciona que no existe un método unirversalmente aceptado o exacto para determinar la Dimensión Vertical Oclusal. Se sugiere la combinación de varios métodos de registro de Dimensión Vertical Oclusal, se debe de considerar la manera más adecuada para lograr un registro más acertado.
ABSTRACT: Occlusal Vertical Dimension is the distance between an anatomical point in the maxilla and another on the mobile part of the mandible when the teeth are in occlusal contact. Obtaining this record determines the vertical space necessary for the rehabilitation of patients. Nowadays there are different methods for the record of the Occlusal Vertical Dimension, in this study the following were analyzed: physiological methods and mechanical methods. The objective was to do a systematic review of the registration methods to determine the Occlusal Vertical Dimension in dentate patients. Scientific information was collected from May 2019 to July 2020 in different electronic databases, finding a total of 13,948 articles, after eliminating repeated articles, by title, by abstract and by PICO methodology, a total of 24 articles were selected for analysis and classification. More than one author mentions that there is no universally accepted or exact method for determining Occlusal Vertical Dimension. A combination of several methods of Occlusal Vertical Dimension registration is suggested; it should be considered the most appropriate way to achieve a more accurate registration.
