Case-control analysis of fundic gland polyps and proton-pump inhibitors. A pathologist's perspective. / Análisis de casos y controles de pólipos de glándulas fúndicas e inhibidores de bomba de protones. La perspectiva de un patólogo.

INTRODUCTION AND AIM: Adequately preserved slides and tissue blocks in pathology archives, when re-reviewed and associated with patient charts, are important tools to further assess prevalence changes and associations of certain pathologies. Our aim was to identify whether proton-pump inhibitor (PPI) use, dose, and duration of use were associated with gastric polyps and their phenotypes in a case-control study. METHODS: The slides from patients with a morphologic diagnosis of either hyperplastic polyps or fundic gland polyps were retrieved from the 1980, 1990, 2000, 2010, and 2016 surgical pathology files at a tertiary care hospital in Mexico City and re-evaluated. Cases were paired by age and sex with patients that underwent endoscopy and gastric mucosa biopsy in the same year, with no evidence of polyps. RESULTS: A total of 133 (3.8%) patients with gastric polyps were identified from 3,499 gastric biopsies taken in the abovementioned years and compared with 133 paired controls. Dyspepsia was more prevalent in the controls (p=0.002) and abdominal pain was more prevalent in the patients with gastric polyps (p=0.001). PPI use (OR 7.7, 95% confidence interval, 4.4-13.3) and taking more than one PPI medication (OR 4.9, 95% confidence interval, 1.09-22.3) were significantly associated with the presence of gastric polyps. The fundic gland phenotype in the oxyntic mucosa was more frequently associated with PPI use (p<0.042), with a continuous increase in its prevalence starting in the year 2000 (p=0.017 for trend). CONCLUSION: PPI administration for at least one year was associated with gastric fundic gland polyps.

[Factors associated with jejunostomy complications]. / Factores asociados a complicaciones de yeyunostomía.

BACKGROUND: There are few studies in the literature that analyze jejunostomy complications and their associated factors. AIMS: To describe the rate of complications and analyze the factors associated with their development in a tertiary reference center in Mexico. METHODS: A retrospective study was carried out on patients that underwent Witzel jejunostomy within the time frame of January 2002 to December 2011. Patient demographic, clinical, and laboratory data were collected at the time of hospital admission and during follow-up. The factors associated with the development of complications were analyzed using the chi square test for categorical variables and the Student's t test for the continuous variables. Statistical significance was considered with a p<.05. RESULTS: One hundred and twelve patients (57 men) with a mean age of 54.2 years were included in the study. Forty-eight patients (42.9%) presented with postoperative complications. The most frequent surgical complications were severe sepsis (11.6%) and septic shock (7.14%) and the most frequent medical complications were pleural effusion (7.14%) and aspiration pneumonia (6.25%). The factors that were significantly associated with the development of complications were obesity, lymphocytopenia, and hypoalbuminemia. CONCLUSIONS: Jejunostomy is associated with an elevated medical, as well as surgical, complication frequency. Even though it has been established as a better alternative to parenteral nutrition, its associated morbidity should be taken into consideration before establishing its routine use as a means of nutritional support, especially in patients with factors associated with the development of complications.