1.
Chem Sci
; 11(33): 9011-9016, 2020 Aug 10.
Article
in English
| MEDLINE
| ID: mdl-34123155
ABSTRACT
We describe the development of TMTH-SulfoxImine (TMTHSI) as a superior click reagent. This reagent combines a great reactivity, with small size and low hydrophobicity and compares outstandingly with existing click reagents. TMTHSI can be conveniently functionalized with a variety of linkers allowing attachment of a diversity of small molecules and (peptide, nucleic acid) biologics.