[Study of the status of energy metabolism in thyrotoxicosis by the insulin test]. / Sostoianie énergeticheskogo obmena pri tireotoksikoze po dannym insulinovoi proby.

The insulin test was carried out in 68 healthy subjects and 20 patients with moderate thyrotoxicosis at the stage of compensation. Blood levels of pyruvate and lactate, plasma and erythrocytic glucose, urinary catecholamines and gas exchange were measured before, 30 and 120 min after intravenous administration of insulin (0.15 U/kg). All the measurements evidenced hypermetabolism: oxygen consumption, carbonic acid production, pulmonary ventilation were enhanced; lactate-pyruvate index and urine catecholamines were lower versus those of healthy subjects. Correlation analysis demonstrated disturbed regulation of hyperventilation by the sympathetic-adrenal system in thyrotoxicosis.

[Characteristics of hormonal regulation in patients with ischemic heart disease after the insulin test combined with physical load]. / Osobennosti gormonal'noi reguliatsii u bol'nykh ishemicheskoi bolezn'iu serdtsa pri sochetannom vozdeistvii insulinovoi proby i fizicheskoi nagruzki.

Nine normal subjects and 6 coronary patients (aged 26 to 53 years) who had survived myocardial infarction more than 3 years before and showed no clinical signs of heart failure, obesity, hypertension and diabetes mellitus, while having normal glucose tolerance test values, were exposed to the insulin test in combination with physical stress in the presence of clinically manifest hypoglycemia. Plasma and erythrocyte glucose and immunoreactive insulin, and urinary excretion of catecholamines were measured. Coronary patients showed considerably increased erythrocyte immunoreactive insulin levels, recorded immediately upon discontinuation of exercise, while their sympathoadrenal hormonal activation was less significant, as compared to normal subjects. The combination of the insulin test and exercise in coronary patients with normal glucose tolerance values helps to detect disturbances of regulatory mechanisms at the erythrocyte level and can be used as an adjuvant method for the assessment of latent carbohydrate metabolic disorders.

[Changes in the systemic and intracardiac hemodynamics of healthy persons as affected by emotional tension]. / Izmeneniia sistemnoi i vnutriserdechnoi gemodinamiki u zdorovykh lits pod vliianiem émotsional'nogo napriazheniia.

Twenty-four normal subjects were examined during exposure to emotional stress, simulated by mental arithmetic exercise under time shortage and interfering light and sound stimuli. Hemodynamic parameters were determined on the basis of echocardiographic M-records in resting condition and under mental stress. Irrespective of the baseline hemodynamic type, emotional stress produced a hyperkinetic circulatory response. Increased cardiac index resulted from higher heart rate in the presence of unchanged venous return and stroke index. Myocardial contractility increased to a greater extent in individuals with hypokinetic and eukinetic hemodynamics.

[Spike activity of neurons of the ventromedial hypothalamus of the rat during stress]. / Impul'snaia aktivnost' neironov ventromedial'nogo gipotalamusa u krys pri stresse.

In fixed Wistar line rats, neuronal activity of the ventromedial hypothalamus was studied in conditions of acute emotional stress elicited by electric stimulation of the ventromedial hypothalamus stochastically alternating with electrocutaneous stimuli. Distinctions were revealed in neuronal activity of the animals with different stress resistance. The pattern of neuronal impulse activity proved to be the most informative one.