Entropy-Based Machine Learning Model for Fast Diagnosis and Monitoring of Parkinson's Disease.

This study presents the concept of a computationally efficient machine learning (ML) model for diagnosing and monitoring Parkinson's disease (PD) using rest-state EEG signals (rs-EEG) from 20 PD subjects and 20 normal control (NC) subjects at a sampling rate of 128 Hz. Based on the comparative analysis of the effectiveness of entropy calculation methods, fuzzy entropy showed the best results in diagnosing and monitoring PD using rs-EEG, with classification accuracy (ARKF) of ~99.9%. The most important frequency range of rs-EEG for PD-based diagnostics lies in the range of 0-4 Hz, and the most informative signals were mainly received from the right hemisphere of the head. It was also found that ARKF significantly decreased as the length of rs-EEG segments decreased from 1000 to 150 samples. Using a procedure for selecting the most informative features, it was possible to reduce the computational costs of classification by 11 times, while maintaining an ARKF ~99.9%. The proposed method can be used in the healthcare internet of things (H-IoT), where low-performance edge devices can implement ML sensors to enhance human resilience to PD.

A Bio-Inspired Chaos Sensor Model Based on the Perceptron Neural Network: Machine Learning Concept and Application for Computational Neuro-Science.

The study presents a bio-inspired chaos sensor model based on the perceptron neural network for the estimation of entropy of spike train in neurodynamic systems. After training, the sensor on perceptron, having 50 neurons in the hidden layer and 1 neuron at the output, approximates the fuzzy entropy of a short time series with high accuracy, with a determination coefficient of R2~0.9. The Hindmarsh-Rose spike model was used to generate time series of spike intervals, and datasets for training and testing the perceptron. The selection of the hyperparameters of the perceptron model and the estimation of the sensor accuracy were performed using the K-block cross-validation method. Even for a hidden layer with one neuron, the model approximates the fuzzy entropy with good results and the metric R2~0.5 ÷ 0.8. In a simplified model with one neuron and equal weights in the first layer, the principle of approximation is based on the linear transformation of the average value of the time series into the entropy value. An example of using the chaos sensor on spike train of action potential recordings from the L5 dorsal rootlet of rat is provided. The bio-inspired chaos sensor model based on an ensemble of neurons is able to dynamically track the chaotic behavior of a spike signal and transmit this information to other parts of the neurodynamic model for further processing. The study will be useful for specialists in the field of computational neuroscience, and also to create humanoid and animal robots, and bio-robots with limited resources.

Artificial Neural Networks for IoT-Enabled Smart Applications: Recent Trends.

In the age of neural networks and the Internet of Things (IoT), the search for new neural network architectures capable of operating on devices with limited computing power and small memory size is becoming an urgent agenda [...].

LogNNet model as a fast, simple and economical AI instrument in the diagnosis and prognosis of COVID-19.

Rapid and effective detection of the diagnosis and prognosis of COVID-19 disease is important in terms of reducing the mortality of the disease and reducing the pressure on health systems. Methods such as PCR testing and computed tomography used for this purpose in current health systems are costly, require an expert team and take time. This study offers a fast, economical and reliable approach for the early diagnosis and prognosis of infectious diseases, especially COVID-19. For this purpose, characteristics of a large population of COVID-19 patients were determined (51 different routine blood values) and calibrated. In order to determine the diagnosis and prognosis of the disease, the calibrated features were run with the LogNNet model. LogNNet has a simple algorithm and performance indicators comparable to the most efficient algorithms available.This approach pointed out that routine blood values contain important information, especially in the detection of COVID-19, and showed that the LogNNet model can be used as an economical, safe and fast alternative tool in the diagnosis of this disease.-In the LogNNet feedforward neural network, a feature vector is passed through a specially designed reservoir matrix and transformed into a new feature vector of a different size, increasing the classification accuracy.-The presented network architecture can achieve 80%-99% classification accuracy using a range of weightings on devices with a total memory size of 1 to 29 kB constrained.-Due to the chaotic mapping procedures, the RAM usage in the LogNNet neural network processing process is greatly reduced. Hence, optimization of chaotic map parameters has an important function in LogNNet neural network application.

Bifurcation and Entropy Analysis of a Chaotic Spike Oscillator Circuit Based on the S-Switch.

This paper presents a model and experimental study of a chaotic spike oscillator based on a leaky integrate-and-fire (LIF) neuron, which has a switching element with an S-type current-voltage characteristic (S-switch). The oscillator generates spikes of the S-switch in the form of chaotic pulse position modulation driven by the feedback with rate coding instability of LIF neuron. The oscillator model with piecewise function of the S-switch has resistive feedback using a second order filter. The oscillator circuit is built on four operational amplifiers and two field-effect transistors (MOSFETs) that form an S-switch based on a Schmitt trigger, an active RC filter and a matching amplifier. We investigate the bifurcation diagrams of the model and the circuit and calculate the entropy of oscillations. For the analog circuit, the "regular oscillation-chaos" transition is analysed in a series of tests initiated by a step voltage in the matching amplifier. Entropy values are used to estimate the average time for the transition of oscillations to chaos and the degree of signal correlation of the transition mode of different tests. Study results can be applied in various reservoir computing applications, for example, in choosing and configuring the LogNNet network reservoir circuits.

Machine Learning Sensors for Diagnosis of COVID-19 Disease Using Routine Blood Values for Internet of Things Application.

Healthcare digitalization requires effective applications of human sensors, when various parameters of the human body are instantly monitored in everyday life due to the Internet of Things (IoT). In particular, machine learning (ML) sensors for the prompt diagnosis of COVID-19 are an important option for IoT application in healthcare and ambient assisted living (AAL). Determining a COVID-19 infected status with various diagnostic tests and imaging results is costly and time-consuming. This study provides a fast, reliable and cost-effective alternative tool for the diagnosis of COVID-19 based on the routine blood values (RBVs) measured at admission. The dataset of the study consists of a total of 5296 patients with the same number of negative and positive COVID-19 test results and 51 routine blood values. In this study, 13 popular classifier machine learning models and the LogNNet neural network model were exanimated. The most successful classifier model in terms of time and accuracy in the detection of the disease was the histogram-based gradient boosting (HGB) (accuracy: 100%, time: 6.39 sec). The HGB classifier identified the 11 most important features (LDL, cholesterol, HDL-C, MCHC, triglyceride, amylase, UA, LDH, CK-MB, ALP and MCH) to detect the disease with 100% accuracy. In addition, the importance of single, double and triple combinations of these features in the diagnosis of the disease was discussed. We propose to use these 11 features and their binary combinations as important biomarkers for ML sensors in the diagnosis of the disease, supporting edge computing on Arduino and cloud IoT service.

Diagnosis and Prognosis of COVID-19 Disease Using Routine Blood Values and LogNNet Neural Network.

Since February 2020, the world has been engaged in an intense struggle with the COVID-19 disease, and health systems have come under tragic pressure as the disease turned into a pandemic. The aim of this study is to obtain the most effective routine blood values (RBV) in the diagnosis and prognosis of COVID-19 using a backward feature elimination algorithm for the LogNNet reservoir neural network. The first dataset in the study consists of a total of 5296 patients with the same number of negative and positive COVID-19 tests. The LogNNet-model achieved the accuracy rate of 99.5% in the diagnosis of the disease with 46 features and the accuracy of 99.17% with only mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, and activated partial prothrombin time. The second dataset consists of a total of 3899 patients with a diagnosis of COVID-19 who were treated in hospital, of which 203 were severe patients and 3696 were mild patients. The model reached the accuracy rate of 94.4% in determining the prognosis of the disease with 48 features and the accuracy of 82.7% with only erythrocyte sedimentation rate, neutrophil count, and C reactive protein features. Our method will reduce the negative pressures on the health sector and help doctors to understand the pathogenesis of COVID-19 using the key features. The method is promising to create mobile health monitoring systems in the Internet of Things.

A Method for Estimating the Entropy of Time Series Using Artificial Neural Networks.

Measuring the predictability and complexity of time series using entropy is essential tool designing and controlling a nonlinear system. However, the existing methods have some drawbacks related to the strong dependence of entropy on the parameters of the methods. To overcome these difficulties, this study proposes a new method for estimating the entropy of a time series using the LogNNet neural network model. The LogNNet reservoir matrix is filled with time series elements according to our algorithm. The accuracy of the classification of images from the MNIST-10 database is considered as the entropy measure and denoted by NNetEn. The novelty of entropy calculation is that the time series is involved in mixing the input information in the reservoir. Greater complexity in the time series leads to a higher classification accuracy and higher NNetEn values. We introduce a new time series characteristic called time series learning inertia that determines the learning rate of the neural network. The robustness and efficiency of the method is verified on chaotic, periodic, random, binary, and constant time series. The comparison of NNetEn with other methods of entropy estimation demonstrates that our method is more robust and accurate and can be widely used in practice.

A Method for Medical Data Analysis Using the LogNNet for Clinical Decision Support Systems and Edge Computing in Healthcare.

Edge computing is a fast-growing and much needed technology in healthcare. The problem of implementing artificial intelligence on edge devices is the complexity and high resource intensity of the most known neural network data analysis methods and algorithms. The difficulty of implementing these methods on low-power microcontrollers with small memory size calls for the development of new effective algorithms for neural networks. This study presents a new method for analyzing medical data based on the LogNNet neural network, which uses chaotic mappings to transform input information. The method effectively solves classification problems and calculates risk factors for the presence of a disease in a patient according to a set of medical health indicators. The efficiency of LogNNet in assessing perinatal risk is illustrated on cardiotocogram data obtained from the UC Irvine machine learning repository. The classification accuracy reaches ~91% with the~3-10 kB of RAM used on the Arduino microcontroller. Using the LogNNet network trained on a publicly available database of the Israeli Ministry of Health, a service concept for COVID-19 express testing is provided. A classification accuracy of ~95% is achieved, and~0.6 kB of RAM is used. In all examples, the model is tested using standard classification quality metrics: precision, recall, and F1-measure. The LogNNet architecture allows the implementation of artificial intelligence on medical peripherals of the Internet of Things with low RAM resources and can be used in clinical decision support systems.

Rapid early development of circumarctic peatlands and atmospheric CH4 and CO2 variations.

An analysis of 1516 radiocarbon dates demonstrates that the development of the current circumarctic peatlands began approximately 16.5 thousand years ago (ka) and expanded explosively between 12 and 8 ka in concert with high summer insolation and increasing temperatures. Their rapid development contributed to the sustained peak in CH4 and modest decline of CO2 during the early Holocene and likely contributed to CH4 and CO2 fluctuations during earlier interglacial and interstadial transitions. Given the decreased tempo of peatland initiation in the late Holocene and the transition of many from fens (which generated high levels of CH4) to ombrotrophic bogs, a neoglacial expansion of northern peatlands cannot explain the increase in atmospheric CH4 that occurred after 6 ka.