[The ulcerostatic effect of the exopolysaccharide from Bacillus mucilaginosus and its possible mechanisms]. / Ul'tserostaticheskii éffekt ékzopolisakharida slizeobrazuiushchikh batsill i ego vozmozhnye mekhanizmy.

The stimulatory action of Bacillus mucilaginosus exopolysaccharide on proliferative processes in experimental gastric ulcer healing. With the drug, the levels of collagen, noncollagen proteins, glycosaminoglycans, DNA, and RNA in the ulcer tissue.

[The antiatherosclerotic effects of a polysaccharide from raw animal stock]. / Antiateroskleroticheskie éffekty polisakharida iz zhivotnogo syr'ia.

The data obtained showed that the polysaccharide diminished the blood levels of cholesterol, beta-lipoproteins, and triglycerides, the concentrations of cholesterol in the liver and thoracic aorta in experimental atherosclerosis. It is concluded that the polysaccharide is promising in designing a new anti-atherosclerotic drug.

[Splenic perfusion in the combined treatment of patients with systemic lupus erythematosus]. / Splenoperfuziia v kompleksnom lechenii bol'nykh sistemnoi krasnoi volchankoi.

Twenty patients suffering from severe systemic lupus erythematosus (SLE) underwent 52 sessions of splenoperfusion (SP) by means of extracorporeal perfusion of the patient's blood through isolated porcine spleen. It got prepared directly before the perfusion. The organ was obtained from a healthy animal in sterile conditions, washed from the blood after cannulation of the artery and vein. The patient's blood was pumped from the peripheral vein to the spleen artery. After passing through the splenic vascular bed the blood outflew from the spleen vein into the opposite peripheral vein of the patient. SP was followed by positive clinical changes: normalization of body temperature, regression of skin symptoms and articular syndrome, reduction of lymphadenopathy, hepato- and splenomegaly. The tests indicated inhibition of SLE activity. Sp-related immunocorrective effect was also present as shown by depression of B-cell hyperreactivity and T-cell immunity stimulation. 1-4-year follow-up of 19 patients showed them to be in remission. The data obtained favour SP inclusion into intensive therapy of severe SLE.

[Possible mechanisms of anti-ulcer action of silatranes]. / K voprosu o vozmozhnykh mekhanizmakh ul'tserostaticheskogo deistviia silatranov.

A stimulating effect of methylethyl(silatrane-I-ilmethyl)-sulphonium iodides, 1-(ethoxy)silatranes and 1-(chloromethyl)silatrane on the processes of rat test acetate ulcer healing is studied. Silatranes efficiency is not inferior to oxyferriscorbone and exceeds that of methacil. It is shown that all preparations inhibit the processes of lipids peroxidation in the blood, in liposomes and stomach tissue.

[The treatment of infectious-allergic bronchial asthma by the extracorporeal connection of a donor spleen]. / Lechenie infektsionno-allergicheskoi bronkhial'noi astmy metodom ékstrakorporal'nogo podkliucheniia donorskoi selezenki.

A total of 25 patients suffering from infective allergic bronchial asthma underwent extracorporeal connection of the donor's spleen (ECCDS). Before ECCDS was made the health status was unstable in all the patients, with asphyxia attacks occurring fairly often, namely up to 12 times a day. Nine patients received the maintenance therapy with steroid hormones. After ECCDS 23 persons (92%) manifested complete disappearance of asphyxia attacks or considerable abatement of their severity and rate. In all the steroid-dependent patients, the daily dosage of steroids could be lowered, while in 3 patients, hormonal drugs were afterwards discontinued. Examination of external respiratory function demonstrated the improvement of bronchial patency at the level of large, medium-size and small bronchi. There was a decrease of the concentration of the circulating immune complexes and IgE in the blood plasma. During 2 years of the follow up, 16 patients did not show any disease relapses, whereas the remainder demonstrated less gravity of attacks as compared to the period preceding the use of ECCDS. It is concluded that the use of ECCDS is desirable in the multimodality treatment of infective allergic bronchial asthma.

[The anticoagulant and antisclerotic effects of isopropoxygermatrane and methylethyl(silatrane-1-ylmethyl)sulfonium iodide]. / Antikoaguliantnye i antiskleroticheskie éffekty izopropoksigermatrana i metilétil (silatran-1-ilmetil[sul'fonii iodida.

In the experiments on rabbits with experimental atherosclerosis the authors revealed lipolytic and antisclerotic effect of the above drug. It was also observed that it also possessed anticoagulation activity.

[Characteristics of neurophysiologic changes in experimental stress induced by long-term group isolation in rats]. / Osobennosti neirofiziologicheskikh izmenenii pri éksperimental'nom stresse, vyzvannom dlitel'noi gruppovoi izoliatsiei u krys.

Long-term sexual conflict situation induced changes in main statistical parameters of firing rate in the hippocampus, amygdala and septum both in intact rats and in those under stress. The latter were shown to reveal an increased number of the neurons with polymodal distribution of interspike intervals in all the structures under study.

[Effect of oxytocin on the activity of posterior hypothalamic neurons in the rat]. / Vliianie oksitotsina na aktivnost' neironov zadnego gipotalamusa u krys.

Changes of unit activity in different nuclei of the posterior hypothalamus induced by intravenous oxytocin injections were studied in acute experiments on Wistar rats anaesthetized with nembutal. Influence of nonapeptide was dose-dependent. Latencies of various neuronal reactions were different. Mechanisms of oxytocin regulation of neuronal activity in the posterior hypothalamus are discussed.