ABSTRACT
The need for a bonding system that is consistently reliable, biocompatible, and most of all, easy to use and is unaffected by saliva contamination, has led to the development of products that did not require the initial step of etching the enamel surface. In these new systems elements of etching, priming and bonding are all in one component. The aim of this study was to compare the bonding strength of brackets with a traditional technique to the Prompt L-Pop (monocomponent adhesive) using the same composite resin. The results showed no statistical differences in detachment values of these two groups.
Subject(s)
Acid Etching, Dental/methods , Dental Bonding/methods , Dental Cements/chemistry , Orthodontic Brackets , Acrylic Resins/chemistry , Bisphenol A-Glycidyl Methacrylate/chemistry , Composite Resins/chemistry , Dental Enamel/ultrastructure , Equipment Failure , Humans , Phosphoric Acids/chemistry , Resin Cements/chemistry , Statistics as Topic , Stress, Mechanical , Tensile Strength , ThermodynamicsABSTRACT
This paper reports the synthesis of 3-substituted-1,2,3-triazolo[1,5-a]quinazolin-5-ones prepared by 1,3-dipolar cycloaddition reaction of 2-azidobenzoic acid to methylenic compounds activated by a cyano group. The new derivatives were submitted to benzodiazepine receptor binding assays: the results indicated an interesting receptorial affinity of the 1,2,3-triazolo[1,5-a]quinazoline ring. On the basis of the biological results, theoretical calculations were performed, which suggested useful structural modifications.
Subject(s)
Quinazolines/chemical synthesis , Receptors, GABA-A/drug effects , Animals , Cattle , Flumazenil/metabolism , Quinazolines/metabolism , Quinazolines/pharmacology , Receptors, GABA-A/metabolism , Structure-Activity RelationshipABSTRACT
This paper reports the continuation of the studies on the 4-aminosubstituted 1,2,3-triazole[4,5-d]pyridazine derivatives which had shown binding affinity towards adenosine receptors. Biological results confirmed the greater activity of a benzyl substituent in the 1 position and the receptorial stereoselectivity related to the higher and more selective A1 affinity of the 4-D(+)-alpha-methylbenzylamino enantiomer 1b. The 4-phenylhydrazino substituent has shown an interesting binding activity about equipotent towards A1 and A2 receptorial sites. A surprisingly elevated A1 affinity (Ki = 7 nM), 440 fold higher than A2 affinity, is presented by compound 1d, bearing a m-toluidino substituent.
