Subject(s)
Endometrial Neoplasms/pathology , Mandibular Neoplasms/secondary , Aged , Fatal Outcome , Female , HumansABSTRACT
BACKGROUND: Patients with mesenchymal chondrosarcomas in general have a 5-year survival rate ranging from 42-54.6% and a 10-year survival rate of 28%. Nineteen cases of mesenchymal chondrosarcoma of the jaw bones were reviewed to study their clinicopathologic features and to compare their clinical behavior with that of mesenchymal chondrosarcomas of other locations. METHODS: The patients were 10 males and 9 females (age range, 2-51 years). Sixteen patients were age < 30 years, and the average age at presentation was 19 years. Eleven tumors involved the mandible and eight involved the maxilla. RESULTS: Histologically, the classic picture of a bimorphic tumor, composed of islands of well differentiated hyaline cartilage juxtaposed to a small cell undifferentiated malignancy, was present in every case. Resection, including hemimandibulectomy and hemimaxillectomy, was the main treatment in 16 patients. Seven patients had local recurrence, and five patients developed distant metastases. Six patients died of disease, and the 5-year and 10-year survival rates were 82% and 56%, respectively. CONCLUSIONS: Mesenchymal chondrosarcoma of the jaw bones appears to have a more indolent course than mesenchymal chondrosarcoma of other anatomic
Subject(s)
Chondrosarcoma/pathology , Jaw Neoplasms/pathology , Adolescent , Adult , Child , Child, Preschool , Chondrosarcoma/surgery , Female , Humans , Jaw Neoplasms/surgery , Male , Mesoderm , Middle Aged , Prognosis , Recurrence , Survival AnalysisABSTRACT
Um novo estoque de Trypanosoma cruzi isolado de paciente chagásico crônico, com a forma digestiva e cardiaca da doença, foi caracterizado através de infecçäo experimental em camundongos isogênicos A/Sn suscetíveis à infecçäo chagásica. As curvas de parasitemia mostraram picos de até 1,7x10**6 parasitas/ml näo se observando mortalidade até 300 dias após infecçäo. anticorpos da classe IgM foram encontrados na fase aguda até 40 dias e também na fase crônica e IgG foi detectada nas fases aguda e crônica. O exame histopatológico mostrou miotropismo para músculo liso do tubo digestivo e cardíaco
Subject(s)
Mice , Humans , Animals , Chagas Disease/parasitology , Trypanosoma cruzi/isolation & purification , Acute Disease , Antibodies, Protozoan/blood , Chronic Disease , Chagas Disease/immunology , Mice, Inbred A , Chagas Cardiomyopathy/parasitologyABSTRACT
A new Trypanosoma cruzi stock isolated from a patient in the chronic phase of Chagas' disease with the digestive and cardiac form of the disease was characterized by experimental infection in isogenic, susceptible, A/Sn strain mice. Parasitemia curves showed up to 1.7 x 10(6) parasites/ml and no mortality was observed up to 300 days post infection. Specific IgM was found in mice in the acute phase up to 40 days and also in the chronic phase. IgG antibodies were detected in the acute and chronic phase. Histopathology examination demonstrated myotropism to the digestive tract muscle layers and to the heart.
