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BMC Pulm Med ; 12: 47, 2012 Sep 04.
Article in English | MEDLINE | ID: mdl-22947057

ABSTRACT

BACKGROUND: Granulomatosis with polyangitis (Wegener's) is a vasculitic disease predominantly affecting the lungs, skin, kidneys, ears, nose and throat. Mycobacterium abscessus is an uncommon rapidly growing mycobacterium causing sporadic lung disease. This is the first report of both GPA and Mycobacterium abscessus pulmonary disease reported in literature. CASE PRESENTATION: We present a case report of a 33 year old Caucasian man with relapsing disease complicated by pulmonary infection with Mycobacterium abscessus. He subsequently required bilateral cochlear implantation for progressive sensori-neural hearing loss. His M. abscessus was treated successfully with a prolonged course of antimicrobial therapy. His Granulomatosis with polyangitis (Wegener's) relapsed towards the end of antimicrobial therapy and required treatment. Shortly after completing his antimicrobial therapy and relapse, he developed progressive dyspnea due to pulmonary fibrosis. CONCLUSION: The potential causes of his progressive dyspnoea are discussed including the potential role of his underlying disease and treatment.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Cochlear Implantation , Disease Progression , Dyspnea/etiology , Granulomatosis with Polyangiitis/drug therapy , Hearing Loss/therapy , Mycobacterium Infections/drug therapy , Adult , Antibodies, Monoclonal, Murine-Derived/therapeutic use , Comorbidity , Cyclophosphamide/therapeutic use , Dyspnea/diagnosis , Granulomatosis with Polyangiitis/epidemiology , Humans , Male , Mycobacterium Infections/epidemiology , Pulmonary Fibrosis/complications , Pulmonary Fibrosis/epidemiology , Recurrence , Remission Induction , Rituximab
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