ABSTRACT
Low mineral water has gained increasing attention due to its potential health implications concerning bone mineral density (BMD) and dental health. Reverse osmosis (RO) systems to purify water are in use extensively, and these systems, in addition to removing impurities from water, also remove 92-99% of beneficial minerals like calcium, lead, fluoride, magnesium, and iron. These minerals are essential for maintaining optimal mineral density of teeth and bones, thereby preserving bone and teeth health. Most of these mineral components are physically larger than water molecules and are trapped by the semi-permeable membrane of RO filters when drinking water is filtered through it. The resultant water is of very poor mineral content, and studies have shown that this water, when consumed, can absorb minerals from the body and eliminate the same through urine. The combined synergistic effect of consumption of low mineral water along with minerals being excreted has been shown to cause demineralization of bones and teeth, increasing the risk of osteoporosis and dental caries. This review tries to address the ill effects of consuming low mineral water along with preventive strategies to overcome its much-concealed adverse effects.
ABSTRACT
Ion transport through porous substrates is ubiquitous in biological and synthetic materials, and fundamental for chemical separation, drug delivery and bio-sensing. Contemporary imaging techniques for simultaneously characterizing topography and ion transport through porous substrates are limited in range and resolution. In this paper, we demonstrate 'surface-tracked scanning ion conductance microscopy' as a technique to image topography of a porous substrate and simultaneously measure voltage-driven transmembrane ion transport. This technique uses the principles of 'shear-force tracking' to image the surface of a polycarbonate track-etch membrane, and chronoamperometry to reconstruct topography-correlated transmembrane ion transport through the membrane at different transmembrane potentials. Spatial transmembrane transport through individual pores is modeled using Goldman-Hodgkin-Katz (GHK) theory to examine the effects of shear-force modulation on magnitude of transmembrane currents recorded with a nanopipette. The modeled transmembrane current through the porous membrane is compared with experimental behavior, and discrepancies between predicted values and measured data are outlined. The proposed surface-tracked imaging mode allows for rapid assessment (approximately 7 s/µm2) of interfacial processes at the nanoscale and addresses a bottleneck for stable, large-area characterization of porous substrates using scanning ion conductance microscopy.
ABSTRACT
Vascular anomalies are localized defects in the vasculature that may or may not be present at birth. There are many types of vascular anomalies with different aetiology and clinical picture and, therefore, require the combined expertise of medical, radiological, and surgical specialities for its diagnosis and management. The term "haemangioma" is used as a common generic label to incorporate all types of vascular malformations. In this report, we describe a case of two maxillary premolars, requiring endodontic therapy, in close proximity to a haemangioma. The challenges encountered in the diagnosis and management of the case are discussed.
