ABSTRACT
PURPOSE: To evaluate the peripapillary RNFL (p-RNFL) thickness changes after vitrectomy for epiretinal membrane (ERM). The relationship between p-RNFL thickness change and visual function was assessed. METHODS: Thirty-five eyes from 35 patients with ERM who underwent vitrectomy with internal limiting membrane (ILM) removal were included. Average p-RNFL and the four quadrants thickness were measured by spectral-domain optical coherence tomography (SD-OCT) before and at one, three, and six months after surgery. RESULTS: At six months after surgery, p-RNFL thickness of the temporal and inferior quadrant was decreased in the operated eyes compared with fellow eyes (p<0.05). Pattern standard deviation (PSD) was higher than that of fellow eyes (p = 0.002). The temporal and inferior quadrant p-RNFL thickness showed a relationship with both best-corrected visual acuity (BCVA) outcome and the six-month PSD (p<0.05, respectively). CONCLUSIONS: The selective decrease in the temporal and inferior p-RNFL thickness after vitrectomy for ERM removal could indicate inner retinal damage related to ILM peeling.
Subject(s)
Epiretinal Membrane/surgery , Optic Disk/pathology , Retinal Ganglion Cells/pathology , Tomography, Optical Coherence/methods , Visual Acuity , Vitrectomy , Aged , Aged, 80 and over , Epiretinal Membrane/diagnosis , Epiretinal Membrane/physiopathology , Female , Follow-Up Studies , Humans , Male , Middle Aged , Postoperative Period , Retrospective StudiesABSTRACT
PURPOSE: To evaluate the effectiveness of low power transpupillary thermotherapy (TTT) in treating juxtafoveal recurrent choroidal neovascularization (CNV) after laser photocoagulation in patients with age-related macular degeneration (ARMD). METHODS: Eight eyes of eight patients with ARMD and juxtafoveal recurrent CNV were treated with low power TTT, delivered using an 810-nm diode laser with 350 mW, 2.0 mm spot, and 1-minute duration. Visual acuity (VA) ranged from 20/100 to 20/50. Treatment effect was evaluated by fluorescein angiography, indocyanine green angiography, and VA measurements (Early Treatment Diabetic Retinopathy Study) at 1-week, 2-week, and monthly follow-up visits. RESULTS: No retinal damage was visible ophthalmoscopically during treatment. At the first follow-up visit, seven eyes had obliteration of CNV and one eye required a second TTT application. VA was unchanged in six eyes, improved in one eye, and worsened in one eye. Recurrences occurred in all eyes between 1 and 7 months after TTT and were treated with photodynamic therapy (PDT). More than two PDT treatments were performed in each eye in the year after recurrence. CONCLUSIONS: Low power TTT is as able to close juxtafoveal recurrent CNV as is high power conventional laser photocoagulation but does not prevent recurrences. Further intervention with TTT in order to treat recurrences is under investigation.
Subject(s)
Choroidal Neovascularization/therapy , Hyperthermia, Induced/methods , Aged , Choroidal Neovascularization/etiology , Coloring Agents , Female , Fluorescein Angiography , Follow-Up Studies , Fovea Centralis , Humans , Indocyanine Green , Low-Level Light Therapy , Macular Degeneration/complications , Male , Pupil , Recurrence , Visual AcuityABSTRACT
Diacereine was given to 40 patients whose age ranged from 45 to 87 years; they were suffering from radiologically controlled osteoarthrosis. The oral dosage was 50 mg twice a day and it was given for 4 weeks. The results were classified good in 78% of the patients. Improvement become usually manifest after 2 weeks from starting treatment. Diarrhoea was the only collateral effect in 15% of the cases. In conclusion, Diacereine gives positive effects on osteoarthrosis treatment.
