ABSTRACT
We performed this prospective, randomised, investigator-masked, parallel-group study to compare Fluorometholone-Gentamicin eye drops with Maxitrol (dexamethasone, neomycin, polymyxin B) eye drops in the reduction of ocular bacterial flora and control of ocular inflammation after cataract surgery. One hundred and twelve (FML-Genta 54, Maxitrol 58) patients of both sexes undergoing cataract and posterior chamber lens implant surgery for visually disabling cataract were enrolled in the study and examined pre-operatively and post-operatively on days 1, 6-8 and 24-34. The baseline parameters were similar in the two study groups. The conjunctival bacterial colony count on day 6-8 post-operatively was significantly less on FML-Genta compared with Maxitrol (p = 0.033). There was no statistically significant difference between the two treatments in the degree of intra-ocular inflammation as assessed by flare and cells in the anterior chamber. Both treatments were judged to be equal in the global assessment of the success of therapy and local tolerance by the study patients and doctors. Fluorometholone-gentamicin eye drops were more effective than Maxitrol eye drops in the reduction of ocular bacterial flora while being as well-tolerated and as effective as Maxitrol in the control of ocular inflammation after cataract surgery.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Anti-Inflammatory Agents/therapeutic use , Cataract Extraction/adverse effects , Fluorometholone/therapeutic use , Fluprednisolone/therapeutic use , Gentamicins/therapeutic use , Neomycin/therapeutic use , Polymyxin B/therapeutic use , Postoperative Complications/prevention & control , Administration, Topical , Aged , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/adverse effects , Anti-Inflammatory Agents/administration & dosage , Anti-Inflammatory Agents/adverse effects , Bacteria/drug effects , Bacteria/growth & development , Colony Count, Microbial , Conjunctiva/microbiology , Double-Blind Method , Drug Combinations , Drug Therapy, Combination , Endophthalmitis/etiology , Endophthalmitis/prevention & control , Eye Infections/etiology , Eye Infections/prevention & control , Female , Fluorometholone/administration & dosage , Fluorometholone/adverse effects , Fluprednisolone/administration & dosage , Fluprednisolone/adverse effects , Gentamicins/administration & dosage , Gentamicins/adverse effects , Glucocorticoids , Humans , Lenses, Intraocular , Male , Neomycin/administration & dosage , Neomycin/adverse effects , Ophthalmic Solutions , Polymyxin B/administration & dosage , Polymyxin B/adverse effects , Postoperative Complications/etiology , Prospective StudiesABSTRACT
We performed a study to evaluate the influence on visual function of intraocular straylight after photorefractive keratectomy (PRK). We present 4 eyes of 4 myopic individuals, who had contacted our clinic for keratorefractive surgical treatment. PRK's were performed with a Summit laser, using a 5 mm ablation zone. The straylight meter was used to measure the amount of intraocular scattered light, the physical cause of glare complaints, before and after PRK. This apparatus uses the direct compensation method to assess the amount of intraocular light scatter. The results showed a significant increase in straylight values, in the tested eyes, during the first two weeks after PRK. After the initial rise, straylight values returned to preoperative levels, except for two eyes that clearly developed a haze higher than grade two. Instead of returning to baseline levels, straylight values remained significantly higher in these eyes.
Subject(s)
Cornea/surgery , Myopia/surgery , Photorefractive Keratectomy , Scattering, Radiation , Vision Disorders/etiology , Adult , Cornea/physiopathology , Female , Humans , Lasers, Excimer , Light , Male , Myopia/physiopathology , Photorefractive Keratectomy/adverse effects , Vision Disorders/physiopathology , Visual AcuityABSTRACT
We are performing a prospective study, with the "Straylight meter", to evaluate the effects of PRK, on intraocular straylight. Results show a significant increase in straylight values, during the first two weeks after treatment. There is no correlation between the amount of haze, and intraocular light scatter.
Subject(s)
Keratoplasty, Penetrating/methods , Myopia/surgery , Adult , Female , Humans , Laser Therapy/methods , Light , Male , Myopia/physiopathology , Prospective Studies , Refraction, Ocular , Scattering, Radiation , Visual AcuityABSTRACT
Glare is a major sequela of the radial keratotomy procedure. We used the straylight meter to measure intraocular light scatter, which is the cause of glare, in eyes after radial keratotomy. This apparatus uses a direct compensation method to assess the amount of intraocular light scatter. Nineteen patients were tested. Nine individuals served as controls. The mean postsurgery time was 60 months. The influence of the number of radial incisions, the pupil size, and the angle of light entering the eye were evaluated with the straylight meter. The results showed straylight values for normal pupil size (mean, 4 mm) to be statistically significantly higher (P = .0044) only for the smallest angle of light deflection studied (3.5 degrees). For dilated pupils (mean, 8 mm), straylight values were statistically significantly higher (P = .00005) for all three angles of light deflection studied. The number of incisions showed no statistically significant relationship to straylight values. Average stray light values were increased by a factor of 1.4 for 4-mm sized pupils and 2.0 for 8-mm sized pupils. There was an overlap in straylight values between the patient population and the control population.
Subject(s)
Keratotomy, Radial/adverse effects , Pupil/physiology , Vision Disorders/etiology , Adult , Humans , Light , Scattering, Radiation , Visual AcuityABSTRACT
The question was raised whether ocular lubricants or artificial tears might have adverse effects on optical clarity of the eye. Eight current commercial products were tested on five young subjects, using the Straylight Meter. No adverse effects were found.
