[The therapeutic utilization of magnesium: medical consequences]. / Etude sur l'utilisation thérapeutique du magnésium: conséquences galéniques.

To optimize a pharmaceutical formulation, one has to take into account physicochemical, biopharmaceutical, therapeutical and technological properties of the active principle. These properties are investigated in the PREFORMULATION phase. The authors envisage dosage form (capsule) of magnesium and describe two aspects of the active principle: therapeutic and biopharmaceutic.

[The bioavailability of paracetamol II. The effect of porosity and mechanical properties of the dosage form on solubility]. / Lyodisponibilité du paracétamol. II. Influence de la porosité et des propriétés mécaniques de la forme galénique sur la dissolution.

The authors attempt to explain differences observed in dissolution rate of twelve different brands of paracetamol (nine tablets and three capsules) in terms of pore structure and tensile strength; the pore structure of both tablets and capsules is investigated by mercury porosimetry. Brands (tablets) which liberate paracetamol rapidly are characterized by a higher porosity value. Higher mean pore diameter signifies less t50 and higher porosity. An increase in tensile strength results in an increase in t50 and a decrease in porosity. Porosity alone cannot dictate the dissolution behaviour of capsules.

[The biodisposition of paracetamol. I. The kinetics of disintegration of some dosage forms]. / Lyodisponibilité du paracétamol. I. Etude de la cinétique de dissolution de quelques spécialités.

The in vitro properties of twelve brands of paracetamol (nine tablets and three capsules), commercialized in France, are studied. Among the brands tested (tablets), Latepyrine and Gynospasmine are characterized by faster and Panasorb by slower dissolution rate. Total time of dissolution varies between 7 and 60 min. In some brands, paracetamol is liberated from the surface of the disintegrated particles and in others the active principle is released by progressive erosion. The presence of a surface active agent enhances liquid penetration in the case of capsules.

[Pharmaceutical engineering in drug formulation]. / Le génie pharmaceutique au service de la formulation des médicaments.

The industrial pharmacist, a "pharmaceutical engineer"? The prospect is tempting if only beneficial to drug quality. The Pharmaceutical Engineering comes from Chemical Engineering and Engineer sciences and allows the pharmacist to achieve his aim. We define here the basis of this recent concept, its intervention and interest in the pharmaceutical sciences, more particularly in formulation.

Cyst formation in gastric heterotopic pancreas: report of two cases.

Cyst formation is an uncommon pathologic finding in heterotopic pancreas. It is sometimes reported in a duodenal location but very rarely in a gastric location and leads to very large lesions of unusual endoscopic and radiographic appearance. Two cases of gastric heterotopic pancreas are described in which cystic zones in the gastric wall were found at preoperative ultrasound or computed tomography.