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1.
Am J Respir Crit Care Med ; 163(5): 1171-5, 2001 Apr.
Article in English | MEDLINE | ID: mdl-11316655

ABSTRACT

Part of the functional benefit provided by lung volume reduction surgery (LVRS) may be related to improvement in respiratory muscle function resulting from changes in diaphragm dimension and configuration. To study these changes, we obtained 3D reconstructions of the muscle using spiral computed tomography in 11 patients with severe emphysema before and 3 mo after surgery, and in 11 normal subjects matched for sex, age, height, and weight. Bilateral LVRS was performed by thoracoscopy in eight patients and by sternotomy in three patients. Acquisitions were made in the supine posture at relaxed FRC, midinspiratory capacity, and TLC. On average, LVRS produced a 51 +/- 11% increase in FEV(1) and a 30 +/- 4% decrease in FRC. The total surface area of the diaphragm (A(di)) and of the zone of apposition (A(ap)) at FRC increased by 17 +/- 4% and 43 +/- 8%, respectively, but the surface area of the dome did not change. Compared with the values recorded in the normal subjects, postoperative values of A(di) and A(ap) at FRC were reduced by 11% (p < 0.05) and 24% (p < 0.005), respectively. The curvature of the dome increased at TLC in the left sagittal plane, but was otherwise unaffected by the procedure. We conclude that LVRS substantially increases A(di) and A(ap), but does not significantly improve diaphragm configuration at FRC.


Subject(s)
Pneumonectomy , Pulmonary Emphysema/surgery , Anthropometry , Diaphragm/diagnostic imaging , Female , Functional Residual Capacity , Humans , Male , Middle Aged , Pulmonary Emphysema/physiopathology , Respiratory Mechanics , Tomography, X-Ray Computed , Total Lung Capacity , Treatment Outcome
2.
J Appl Physiol (1985) ; 90(3): 1025-30, 2001 Mar.
Article in English | MEDLINE | ID: mdl-11181615

ABSTRACT

We present a critical assessment of qualitative diagnostic calibration (QDC), which claims to provide a relative calibration of respiratory inductive plethysmography during natural breathing (Sackner MA, Watson H, Belsito AS, Feinerman D, Suarez M, Gonzalez G, Bizousky F, and Krieger B. J Appl Physiol 66: 410-420, 1989). QDC computes the calibration factor (K) by considering breaths of constant tidal volume (VT) and provides a criterion to select breaths when VT is unknown. We applied QDC on uncalibrated data constructed from simulated sets of thoracic and abdominal volumes, with a predefined K. As expected, QDC yields a correct K when applied to breaths at constant VT. In breathing at quasi-constant VT, the criterion for breath selection is shown to bias the results toward K = 1. For spontaneous breathing, the calculated K deviates from its predefined value and depends heavily on the selection criterion. We conclude that QDC will only provide a correct calibration factor when applied to an entire set of breaths with constant or quasi-constant VT. More generally, physiological conclusions based on QDC should be critically evaluated on a case-by-case basis.


Subject(s)
Models, Biological , Plethysmography , Respiration , Respiratory Mechanics , Abdomen , Calibration , Humans , Mathematics , Regression Analysis , Thorax , Tidal Volume
3.
J Appl Physiol (1985) ; 89(6): 2407-12, 2000 Dec.
Article in English | MEDLINE | ID: mdl-11090596

ABSTRACT

We studied the ventilation-perfusion matching pattern in normal gravity (1 G) and short- and long-duration microgravity (microG) using the cardiogenic oscillations in the sulfur hexaflouride (SF(6)) and CO(2) concentration signals during the phase III portion of vital capacity single-breath washout experiments. The signal power of the cardiogenic concentration variations was assessed by spectral analysis, and the phase angle between the oscillations of the two simultaneously expired gases was obtained through cross-correlation. For CO(2), a significant reduction of cardiogenic power was observed in microG, with respect to 1 G, but the reduction was smaller and more variable in the case of SF(6). A shift from an in-phase condition in 1 G to an out-of-phase condition was found for both short- and long-duration microG. We conclude that, although the distribution of ventilation and perfusion becomes more homogeneous in microG, significant inhomogeneities persist and that areas of high perfusion become associated with areas of relatively lower ventilation. In addition, these modifications seem to remain constant during long-term exposure to microG.


Subject(s)
Ventilation-Perfusion Ratio , Weightlessness , Carbon Dioxide , Heart/physiology , Humans , Male , Oscillometry , Respiration , Sulfur Hexafluoride , Time Factors
4.
J Appl Physiol (1985) ; 88(4): 1295-302, 2000 Apr.
Article in English | MEDLINE | ID: mdl-10749822

ABSTRACT

Discrepancies in the assessment of thoracoabdominal asynchrony are observed depending on the choice of respiratory movement sensors. We test the hypothesis that these discrepancies are due to a different dependence of the sensors on cross-sectional perimeter and area variations of the chest wall. First, we study the phase shift between perimeter and area (Phi(PA)) for an elliptical model, which is deformed by sinusoidal changes of its principal axes. We show that perimeter and area vary sinusoidally in the physiological range of deformations, and we discuss how Phi(PA) depends on the ellipticity of the cross section, on the ratio of transverse and dorsoventral movement amplitudes, and on their phase difference. Second, we compute the relationship between perimeter, area, and the output of the inductive sensor, and we proceed by comparing inductive plethysmography with strain gauges for several cross section deformations. We demonstrate that both sensors can provide different phase information for identical cross section deformations and, hence, can estimate thoracoabdominal asynchrony differently. Furthermore, the complex dependence of the inductive sensor on perimeter and area warns against this sensor for the evaluation of thoracoabdominal asynchrony.


Subject(s)
Abdomen , Models, Biological , Respiratory Mechanics/physiology , Respiratory Muscles/physiology , Thorax , Humans , Movement , Plethysmography , Sensitivity and Specificity , Stress, Mechanical
6.
Am J Respir Crit Care Med ; 159(6): 1992-7, 1999 Jun.
Article in English | MEDLINE | ID: mdl-10351950

ABSTRACT

We used three-dimensional reconstructions obtained with spiral computed tomography to measure total diaphragm surface area (Adi), and the surface area of the dome (Ado) and of the zone of apposition (Aap) of the diaphragm in nine patients with single-lung transplantation (SLT) for emphysema and nine normal subjects matched for age, sex, height, and weight. Measurements were obtained at supine FRC, midinspiratory capacity, and TLC. In the normal subjects, Ado and Adi were greater on the right than on the left side, and the right dome was positioned more cranially than the left one, presumably because of the presence of the liver. Compared with either the ipsilateral side in the controls or the native side in the patients, Ado was smaller on the transplanted side because the mediastinum was shifted toward the graft. Adi showed a similar trend. On the other hand, the radius of curvature of the dome in the coronal and sagittal planes was similar on the side of the graft and on the ipsilateral side in the controls. In conclusion, we found that after SLT for emphysema, diaphragm configuration comes back to normal but Ado, and with it Adi, remain smaller than in normal subjects because the mediastinum is displaced toward the graft.


Subject(s)
Diaphragm/diagnostic imaging , Emphysema/diagnostic imaging , Emphysema/surgery , Lung Transplantation , Tomography, X-Ray Computed , Adult , Emphysema/physiopathology , Female , Functional Residual Capacity/physiology , Humans , Inspiratory Capacity/physiology , Lung/physiopathology , Male , Middle Aged , Postoperative Period , Reference Values , Total Lung Capacity/physiology
7.
Comput Biomed Res ; 32(1): 56-66, 1999 Feb.
Article in English | MEDLINE | ID: mdl-10066355

ABSTRACT

A new method for the analysis of heart rate variability in short-term recordings is presented which consists of an analysis of the respiratory sinus arrhythmia in the time domain by means of a polar representation. Its main advantage is that it is applicable in experiments in which the respiration of the subject is not controlled. The algorithm is applied to data recorded on two astronauts during the Euromir-95 space mission. Statistical hypothesis tests demonstrate that the presence of a mouthpiece induces an increase of the respiratory sinus arrhythmia amplitude.


Subject(s)
Algorithms , Arrhythmia, Sinus/physiopathology , Heart Rate/physiology , Respiratory Physiological Phenomena , Analysis of Variance , Electrocardiography , Humans , Models, Cardiovascular , Space Flight
8.
Phys Rev B Condens Matter ; 48(12): 8651-8657, 1993 Sep 15.
Article in English | MEDLINE | ID: mdl-10007078
9.
Appl Opt ; 30(15): 1885-6, 1991 May 20.
Article in English | MEDLINE | ID: mdl-20700152

ABSTRACT

We present a simple method to determine the duration of short laser pulses by measuring the efficiency of a second harmonic generation experiment.

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