Subject(s)
General Surgery/history , History, 19th Century , History, 20th Century , Russia (Pre-1917) , USSRABSTRACT
The article proves the presence of angiogenic activity of the original specimen of biological genesis obtained from the embryogenic human brain tissue. The investigation was carried out on ischemia models of the rat's myocardium and hind limb.
Subject(s)
Brain/embryology , Growth Substances , Hindlimb/blood supply , Ischemia/therapy , Myocardial Ischemia/therapy , Neovascularization, Physiologic , Animals , Humans , Male , Muscle, Skeletal/blood supply , Rats , Time FactorsABSTRACT
Some natural peptides, referred to as cytomedines, were isolated from different organs: cortexin and epithalamin (both from the brain), cordialin (heart), hepalin (liver) and thymalin (thymus),--to test their stimulating effects on the growth in organotypic culture of different tissue explants taken from 3 day old rats. It has been found that these peptides exerted their obvious stimulating effects on the growth of the cultured explants, compared to the control, if taken in the respective concentrations: 100, 50, 50, 100 and 5 ng/ml. Thus, these cytomedins can be used in the clinical practice for stimulating reparative processes in the appropriate tissues.
Subject(s)
Organ Culture Techniques , Peptides/pharmacology , Animals , Brain/growth & development , Dose-Response Relationship, Drug , Heart/drug effects , Heart/growth & development , Liver/drug effects , Liver/growth & development , Rats , Rats, Wistar , Thymus Gland/drug effects , Thymus Gland/growth & developmentABSTRACT
The authors have generalized data on 22 primary tumors of the diaphragm published in our national literature for the period up to 1983. A detailed analysis of a case observed by the authors is given. Benign fibroma of the left-side cupola of the diaphragm weighed 1100,0. Multiple metastases were revealed 1,5 year later first into the postoperative cicatrix, then into the lungs and body. The histological examination has established the diagnosis of fibrosarcoma. The patient survived for 3 years after the first operation. The authors recommend a thorough roentgenological examination to be made for a correct diagnosis of the diaphragm tumor. In all the cases the benign tumor should be dissected with the portion of the diaphragm within the necessary limits.