Haploidentical vs. HLA-matched donor hematopoietic stem-cell transplantation for pediatric patients with acute lymphoblastic leukemia in second remission: A collaborative retrospective study of the Spanish Group for Bone Marrow Transplantation in Children (GETMON/GETH) and the Spanish Childhood Relapsed ALL Board (ReALLNet).

Introduction: Studies addressing the role of haploidentical as alternative to HLA-matched donors for stem cell transplantation (SCT) often include patients with diverse hematological malignancies in different remission statuses. Methods: We compared outcomes of children with acute lymphoblastic leukemia (ALL) undergoing SCT in second complete remission (CR2) from haploidentical (n = 25) versus HLA-matched donor (n = 51). Results: Patients were equally distributed across both groups according to age, immunophenotype, time to and site of relapse, relapse risk-group allocation, and minimal residual disease (MRD) before SCT. Incidence of graft failure, acute graft versus host disease (GVHD), and other early complications did not differ between both groups. We found no differences in overall survival (58.7% versus 59.5%; p = .8), leukemia free survival (LFS) (48% versus 36.4%; p = .5), event free survival (40% versus 34.4%; p = .69), cumulative incidence (CI) of subsequent relapse (28% versus 40.9%; p = .69), treatment related mortality (24% versus 23.6%; p = .83), CI of cGVHD (4.5% versus 18.7%; p = .2), and chronic GVHD-free and leukemia-free survival (44% versus 26.3%; p = .3) after haploidentical donor SCT. Chronic GVHD (HR = 0.09; p=.02) had protective impact, and MRD ≥ 0.01% before SCT (HR = 2.59; p=.01) had unfavorable impact on LFS. Discussion: These results support the role of haploidentical donor SCT in children with ALL in CR2.

Impact of COVID-19 in paediatric early-phase cancer clinical trials in Europe: A report from the Innovative Therapies for Children with Cancer (ITCC) consortium.

INTRODUCTION: Data regarding real-world impact on cancer clinical research during COVID-19 are scarce. We analysed the impact of the COVID-19 pandemic on the conduct of paediatric cancer phase I-II trials in Europe through the experience of the Innovative Therapies for Children with Cancer (ITCC). METHODS: A survey was sent to all ITCC-accredited early-phase clinical trial hospitals including questions about impact on staff activities, recruitment, patient care, supply of investigational products and legal aspects, between 1st March and 30th April 2020. RESULTS: Thirty-one of 53 hospitals from 12 countries participated. Challenges reported included staff constraints (30% drop), reduction in planned monitoring activity (67% drop of site initiation visits and 64% of monitoring visits) and patient recruitment (61% drop compared with that in 2019). The percentage of phase I, phase II trials and molecular platforms closing to recruitment in at least one site was 48.5%, 61.3% and 64.3%, respectively. In addition, 26% of sites had restrictions on performing trial assessments because of local contingency plans. Almost half of the units suffered impact upon pending contracts. Most hospitals (65%) are planning on improving organisational and structural changes. CONCLUSION: The study reveals a profound disruption of paediatric cancer early-phase clinical research due to the COVID-19 pandemic across Europe. Reported difficulties affected both patient care and monitoring activity. Efforts should be made to reallocate resources to avoid lost opportunities for patients and to allow the continued advancement of oncology research. Identified adaptations to clinical trial procedures may be integrated to increase preparedness of clinical research to futures crises.

Los movimientos sociales. De la crítica de la modernidad a la denuncia de la globalización / The social movements. Of the critic of modernity to the denunciation of the globalizacion

Los movimientos sociales tienen una muy larga historia pero su tratamiento específico como actores políticos, sociales y culturales es relativamente reciente. Su especificidad como tales respecto de los partidos, grupos de interés u Organizaciones No Gubernamentales ha sido objeto de controversia. No obstante, existe amplio consenso sobre la relevancia que tienen en aquéllos los rasgos de desafío, acción colectiva, conflicto, voluntad de cambio, organización duradera y repertorio de acciones principalmente no convencionales.Todas esas características facilitan la construcción de una identidad colectiva, siempre en proceso de renegociación, basada en la denuncia de alguna injusticia y tratando para ello de cambiar la agenda política y el "sentido común" dominante en, al menos, una esfera de la vida determinada. Este trabajo presenta un análisis de la evolución de los "nuevos" movimientos sociales y su crítica de la Modernidad, de los límites de la política institucional y del estado del bienestar y, después de los cambios durante la década de los 90 del pasado siglo, una interpretación del desarrollo de "novísimos" movimientos sociales globales en un contexto muy diferente de "globalización" neoliberal y crisis del estado de bienestar

The social movements have a very long history but their analysis as cultural, social and political actors is relatively new. Their specificity as different of parties, interest groups or Non Governmental Organisations has been very controverted. Nevertheless, there is a large consensus on the relevance, among these movements, of the features of challenge, collective action, conflict, will of change, lasting organisation and repertory of actions mainly unconventional. All these traits help to build a collective identity, always in process of renegotiation, based in the denunciation of some injustice and trying to change the political agenda and the dominant "common sense", at least, in some sphere of the life. This paper offers an analysis of the evolution of the "new" social movements and their critique of Modernity, the institutional politics and the welfare state and, after the changes in the nineties of the past century, an interpretation of the development of "very new" global social movements in a very different context of neoliberal "globalisation" and crisis of the welfare state