[Interferon alpha 2ß, partial keratectomy and amniotic membrane transplant for the treatment of a recurrent conjunctival squamous carcinoma]. / Interferón alfa 2-ß, queratectomía parcial y trasplante de membrana amniótica para el tratamiento de un carcinoma escamoso conjuntival recidivante.

CASE REPORT: An 80-year-old woman diagnosed with a recurrent squamous conjuctival carcinoma treated with surgical excision of the lesion, zonal reconstruction and topical Interferon alpha 2-ß. DISCUSSION: Squamous conjunctival carcinoma is the most frequent neoplasm of the ocular surface. Surgical removal of the lesion is the traditional treatment, but this technique has a high recurrence rate. Interferons are glycoproteins that trigger intracellular pathways with antiviral and antitumoral properties. Recent studies have proven their activity against conjunctival carcinoma.

Interferón alfa 2-b, queratectomía parcial y trasplante de membrana amniótica para el tratamiento de un carcinoma escamoso conjuntival recidivante / Interferon alpha 2b, partial keratectomy and amniotic membrane transplant for the treatment of a recurrent conjunctival squamous carcinoma

Caso clínico: Mujer de 80 años de edad diagnosticada de carcinoma escamoso conjuntival recidivante tratado con escisión quirúrgica de la lesión, reconstrucción zonal e interferónalfa 2-b tópico. Discusión: La neoplasia escamosa de la conjuntiva y córnea es el tumor más frecuente dela superficie ocular. La cirugía mediante resección de la lesión es el método tradicional de tratamiento de estos tumores, pero presenta un elevado índice de recurrencias. La inmunoterapia es una alternativa actual para estos tumores. Los interferones son glicoproteínasque actúan activando una cascada de eventos intracelulares que confieren una actividad antivirales y antitumoral. Su actividad frente a las neoplasias epiteliales de la superficieocular se ha demostrado en los últimos años(AU)

Case report: An 80-year-old woman diagnosed with a recurrent squamous conjuctival carcinoma treated with surgical excision of the lesion, zonal reconstruction and topical Interferonalpha 2-b. Discussion: Squamous conjunctival carcinoma is the most frequent neoplasm of the ocularsurface. Surgical removal of the lesion is the traditional treatment, but this technique has a high recurrence rate. Interferons are glycoproteins that trigger intracellular path ways with antiviral and antitumoral properties. Recent studies have proven their activity againstconjunctival carcinoma(AU)

[Long-term clinical outcome of radial optic neurotomy]. / Evolución clínica de la neurotomía óptica radial a largo plazo.

PURPOSE: To study the long-term clinical outcome through assessment of anatomical and functional results, as well as complications of eyes affected with central retinal vein occlusion (CRVO) that underwent radial optic neurotomy (RON). METHODS: Retrospective, observational and descriptive study of 47 eyes corresponding to 47 patients affected by CRVO. All the eyes underwent RON performed by the same surgeon since 2002. The main assessed variables were visual acuity (VA), intraocular pressure (IOP), presence of iris neovascularization and opticocilliary veins, vascular recanalization and complications derived from this pathological entity. RESULTS: Surgery was performed in 47 eyes, 21 of them (44.7%) were right sided and 26 left sided (55.3%). Mean age was 58.97 years. Mean post-surgical follow-up was 32.15 months. A total of 70.2% of the patients experienced stabilization or VA improvement, 23.4% iridian neovascularisation and 42.6% developed opticocilliary veins in the head of the optical nerve. CONCLUSIONS: It is noticeable that in selected cases, RON produces a quick resolution of the retinal haemorrhage and papillary congestion and may improve the retinal perfusion. Long-term benefits are stabilization or improvement of the VA and a reduction in complications on the natural history in CRVO.