1.
Chem Commun (Camb)
; 48(65): 8084-6, 2012 Aug 21.
Article
in English
| MEDLINE
| ID: mdl-22767326
ABSTRACT
A new method is presented to prepare strained lactams. Esterification of the C-terminus of a dipeptide with ß-nitrostyrene or quinoline-type auxiliaries is followed by lactam formation by an intramolecular aza-Michael-acyl-transfer reaction cascade. Ultimately, the cyclic tetrapeptide cyclo[Phe-Tyr-Ala-Gly] has been prepared.