Subject(s)
Anti-Bacterial Agents/therapeutic use , Antiretroviral Therapy, Highly Active , HIV Infections/drug therapy , Helicobacter Infections/drug therapy , Lymphoma, Large B-Cell, Diffuse/microbiology , Stomach Neoplasms/microbiology , HIV Infections/complications , Helicobacter Infections/complications , Helicobacter Infections/virology , Humans , Lymphoma, Large B-Cell, Diffuse/diagnosis , Male , Middle Aged , Remission Induction , Stomach Neoplasms/diagnosisABSTRACT
A 61-year-old male patient with metastatic poorly differentiated squamous cell carcinoma of the larynx to lymph nodes and lung was treated with a third-line chemotherapy regimen of paclitaxel, nimotuzumab and low-dose methotrexate, receiving a total of 30 cycles. The response was complete and maintained at 16 months. Nimotuzumab is a humanized monoclonal antibody used to treat squamous cell carcinomas of the head and neck. This third-line chemotherapy combination with paclitaxel-nimotuzumab-methotrexate seems to be an active combination and needs further evaluation in clinical trials to validate its use in heavily treated patients.
Subject(s)
Antibodies, Monoclonal, Humanized/therapeutic use , Antineoplastic Agents/therapeutic use , Carcinoma, Squamous Cell/drug therapy , Head and Neck Neoplasms/drug therapy , Methotrexate/therapeutic use , Paclitaxel/therapeutic use , Carcinoma, Squamous Cell/pathology , Head and Neck Neoplasms/pathology , Humans , Lung Neoplasms/secondary , Lymphatic Metastasis , Male , Middle Aged , Multimodal Imaging , Positron-Emission Tomography , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
Sixteen cases of granulomatous mastitis were seen in the Breast Clinic of the Rio Blanco Regional Hospital in Veracruz, México. The mean age was 41.7 years (range 22-62), mean previous pregnancies was 5. Lactancy in last 6 months was registered in 50% of the cases, but no cases of puerperal mastitis were seen. Seventy five percent of the patients presented with a breast mass (mean 6 cm), suspicious of cancer in 62.5%. In 2 of 16 cases (12.5) there was an associated breast carcinoma, and in one case tuberculosis was the etiology. Surgical treatment consisted in wide local excision in 100% and mastectomy in 2 cases. Steroids were not used. Recurrent disease was seen in 2 cases at a mean follow-up of 20 months. Awareness of this rare entity is important for the surgeon and the pathologist because the definitive diagnosis is made microscopically, through evaluation of a wide breast tissue sample.
Subject(s)
Breast Neoplasms/diagnosis , Granuloma/diagnosis , Mastitis/diagnosis , Adult , Breast Neoplasms/pathology , Breast Neoplasms/surgery , Diagnosis, Differential , Female , Granuloma/pathology , Granuloma/surgery , Humans , Mastitis/pathology , Mastitis/surgery , Middle Aged , Retrospective StudiesABSTRACT
The functional levels of AT-III were determined to the following groups: A. Eleven healthy non pregnant women B. Thirteen healthy pregnant women (third trimester). C. Six preeclamptic patients. D. Five patients with eclampsia and/or HELP syndrome. The results were as follows: [table: see text] A different grade of DIC may explain the low activity of AT-III in preeclampsia and a more severe coagulation disorder in eclampsia and HELP syndrome. Our preliminary results encourage other prospective studies including larger populations to determine its usefulness as early diagnostic test and severity marker of the disease.
Subject(s)
Antithrombin III/analysis , Eclampsia/blood , Pre-Eclampsia/blood , Pregnancy , Serine Proteinase Inhibitors/blood , Adult , Female , Humans , Pilot Projects , Pregnancy Trimester, Third , Prospective StudiesABSTRACT
We assayed D-Dimer levels in the different stages of preeclampsia. This test appears to be the most reliable for the probability of abnormal status in patients with disseminated intravascular coagulation. Data were analyzed by dividing all cases in four groups: a.-Healthy non pregnan women (10 cases) 550 ng/ml mean levels. B.-Normal pregnant women (8 cases) 875 ng/ml mean levels. C.-Mild and severe preeclamptic patients (8 cases) 1625 ng/ml mean levels, and D.-Eclampsia and HELLP patients (6 cases) 3000 ng/ml. This results were statistical significant at level p < 0.05. It is believed that pregnancy is associated with "hypercoagulability" that it is enhance in toxemia cases. It is necessary to perform more studies with quantitative elisa techniques of D-Dimer, more cases and other markers of dic and endothelial cell injury.
Subject(s)
Disseminated Intravascular Coagulation/diagnosis , Eclampsia/blood , Receptors, Peptide/analysis , Adolescent , Adult , Apgar Score , Eclampsia/diagnosis , Female , HELLP Syndrome/blood , HELLP Syndrome/diagnosis , Humans , Infant, Newborn , Pilot Projects , Pre-Eclampsia/blood , Pre-Eclampsia/diagnosis , PregnancyABSTRACT
OBJECTIVE: To describe the results of treatment of 36 consecutive children with acute lymphoblastic leukemia attending a second level community hospital in the Mexican State of Veracruz. CHARACTERISTICS OF THE CHILDREN: They were from families with very poor resources seen free of charge. Most (75%) were high risk cases. The most common high risk factors were an age outside the range of 2 to 9 years (53%), a WBC count above 50 thousand/microL (36%) and an L-2 lymphocyte morphology (39%). RESULTS OF TREATMENT: Disease-free survival was 64% at 36 months whereas event-free survival was 47% at 36 months which are low in comparison with the data in the literature. CONCLUSIONS: We believe we were able to obtain good results in the treatment of our leukemic cases which was not only a mostly high risk group but also had to contend with poor nutritional, cultural and socioeconomic conditions and with disease-related factors present in their communities.