ABSTRACT
Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is a severe form of encephalitis that has been identified within the context of acute neuropsychiatric manifestations. We report the case of an 18-year-old adolescent referred for a first episode of acute psychosis. The clinical picture rapidly deteriorated to a state of catatonia, decreased consciousness and autonomic instability. Detection of highly positive anti-NMDA-R antibodies confirmed the diagnosis of anti-NMDA-R encephalitis. Immunosuppressive treatment and repeated plasma exchange resulted in slow recovery. The literature on diagnosis and treatment of this specific type of encephalitis is reviewed.
Subject(s)
Anti-N-Methyl-D-Aspartate Receptor Encephalitis/complications , Psychotic Disorders/etiology , Adolescent , Anti-N-Methyl-D-Aspartate Receptor Encephalitis/therapy , Cyclophosphamide/therapeutic use , Diagnosis, Differential , Female , Humans , Immunosuppressive Agents/therapeutic use , Methylprednisolone/therapeutic use , Plasma Exchange , Psychotic Disorders/therapyABSTRACT
We report the case of a 57-year-old lady presenting with a Nocardia asiatica infection in Belgium. No predisposing conditions were found except for an underlying asthma. We reviewed the literature and discussed the role of linezolid in the treatment of nocardiosis.
