Changes in State Mindfulness are the Key to Success in Mindfulness Interventions: Ecological Momentary Assessments of Predictors, Mediators, and Outcomes in a Four-Week Koru Mindfulness Intervention.

It is often assumed that changes in state mindfulness coupled with a decrease in intrusive thinking (e.g., rumination or worry) are the crucial ingredients in mindfulness interventions. We investigate this claim by examining within-person day-to-day changes and causal relationships among these changes in state measures of mindfulness, cognitive interference (a measure of intrusive thinking), depression, well-being, stress, sleep, physical activity, and quality of formal and informal mindfulness practice in a four-week randomized controlled mindfulness intervention with a sample of college students using the Koru mindfulness program; n = 55 for intervention, n = 57 for control; mean age = 21.4). The intervention was effective in improving day-to-day state mindfulness, cognitive interference, and sleep (the effects on all three were linear), but the effects on physical activity, depression, and well-being were not significant. Day-to-day mindfulness (the independent variable) was a predictor of change in daily cognitive interference (the mediating variable), which in turn predicted depression and well-being (dependent variables). The beneficial effects of state mindfulness were demonstrable over a lag of four days, suggesting it is indeed a key ingredient in the effectiveness of mindfulness interventions. Physical activity, sleep, and practice quality did not mediate any effects. One clear implication is that maintaining or restoring high levels of mindfulness, for instance by engaging in meditation or in more informal mindfulness exercises, would be of obvious and direct benefit to mental health and well-being.

An updated account of overgeneral autobiographical memory in depression.

Previous meta-analyses on Overgeneral Autobiographical Memory (OGM) and depression have emphasised clinically diagnosed current depression, leaving questions about subthreshold and remitted depression. Further, numerous studies of OGM remain unconsidered due to a focus on one testing paradigm, the Autobiographical Memory Test (AMT). We conducted a meta-analysis on OGM in depression including remitted, subthreshold, and currently depressed samples and incorporating non-AMT studies. Our novel use of three-level models enabled robust variance analyses with multiple effect sizes from each study while controlling for dependencies across effect sizes. With results from 67 published and unpublished works, ours is the largest meta-analysis to date on OGM in depression. We identified decreased autobiographical memory specificity (Hedges' g = -0.73) and increased categoricity (Hedges' g = 0.77) for depressed individuals over controls. Moderator analyses suggested more severe OGM in current, clinical MDD than subthreshold and remitted depression, although deficits were still present in the latter groups. Our results highlight the importance of utilising a broader range of testing paradigms and considering non-clinical depression in future work.

The Effects of Mindfulness Interventions on Older Adults' Cognition: A Meta-Analysis.

OBJECTIVES: To examine the effect of mindfulness interventions on cognitive tasks in healthy older adults and older adults with diagnoses of mild cognitive impairment (MCI) or dementia. METHODS: Three-level meta-analysis and systematic review of 30 published randomized-controlled trials. RESULTS: Mindfulness interventions provided a small, yet significant positive effect on cognition compared to a control group (average weighted Hedges' g = 0.36, 95% confidence interval [CI] [0.06-0.65]). Attention (g = 0.22, 95% CI = [0.09, 0.35]), long-term memory (g = 0.32, 95% CI = [0.08, 0.56]), and visuospatial processing (g = 0.22, 95% CI = [0.10, 0.34]) all showed significantly meaningful changes regardless of cognitive status of the participants. There was no evidence for publication bias. Healthy older adults showed higher effect sizes than those with MCI (g = 0.27, 95% CI = [0.11, 0.43], vs. (g = -0.09, 95% CI = [-0.35, 0.17], respectively). Otherwise, there were no significant moderating effects of age, marital status, education, region, intervention type, length, number of sessions, adherence, or gender on effect size. Moderator analyses within cognitive domains suggest that focused attention practices might be the best for improving cognition. Lastly, meditation interventions seem to work as effectively as other mind-body interventions, but not as effectively as other interventions to improve cognitive functioning in older adults. DISCUSSION: Mindfulness interventions appear to be a useful tool for improving cognitive functioning in older adults.

Letting Go as an Aspect of Rumination and Its Relationship to Mindfulness, Dysphoria, Anxiety, and Eudemonic Well-Being.

Background: We examined how a newly proposed facet of rumination, that is, the (in)ability to let go, might relate to other aspects of rumination and to psychological outcomes. Methods: In two independent samples (n = 423 and 329, resp.) of college students, we measured a broad set of rumination and rumination-related measures, letting go, anxiety and dysphoria; in the second sample, we also collected data on mindfulness, self-compassion and eudemonic well-being. Results: Factor analysis of rumination and rumination-related measures yielded three factors: (a) negative intrusive thought; (b) reflectiveness; and (c) the inability to let go. Repetitive intrusive thought and the ability to let go were significant (and thus partially independent) predictors for the three outcomes of anxiety, dysphoria, and wellbeing. The inability to let go and repetitive intrusive thought significantly mediated between mindfulness and all three outcomes. Conclusions: The findings suggest that letting go is a potentially interesting aspect of rumination not fully captured in the traditional concept of rumination and its standard measures.

Mind full of kindness: self-awareness, self-regulation, and self-transcendence as vehicles for compassion.

BACKGROUND: We investigated the relationship between mindfulness and compassion in a broader way than is typically done by (a) using a recent, comprehensive conceptualization of mindfulness as a manifold of self-awareness, self-regulation, and self-transcendence, and (b) by casting a wide net of compassion measures [i.e., the Compassionate Love for Humanity Scale (Sprecher and Fehr in J Soc Pers Relatsh 22(5):629-651, 2005); Compassion Scale (Martins et al. in J Health Care Poor Underserved 24:1235-1246, 2013); Compassion Scale (Pommier in Assessment 27:21-39, 2020); Relational Compassion Scale (Hacker in The relational compassion scale: Development and validation of a new self-rated scale for the assessment of self-other compassion, University of Glasgow, 2008); and the SOCS-O scale (Gu et al. in Clin Psychol Rev 37:1-12, 2020)]. Additionally, we examined the interplay between mindfulness, compassion, and ethical sensitivities by assessing the influence of the moral foundations (individualizing and binding) on compassion, and the influence of mindfulness, the moral foundations, and compassion on awareness of privilege. METHODS: We surveyed 407 undergraduate students. Factor analysis was used to examine the dimensionality of the compassion measures; path analysis to examine the relationships between all variables. RESULTS: Factor analysis revealed distinct affective (empathy, indifference), cognitive (common humanity, recognizing suffering), and motivational (willingness to act) aspects of compassion. Mindfulness, under its aspects of reflective awareness, self-compassion, and self-transcendence, was associated with compassion, with reflective awareness predicting multiple aspects of compassion over and beyond the normal mechanisms of the mindfulness manifold and the moral foundations. Individualizing was associated with all aspects of compassion; binding was only connected to recognizing suffering and a willingness to act. Awareness of privilege was positively connected to mindfulness through individualizing and the recognition of common humanity; it was also directly negatively related to the moral foundation of binding. CONCLUSIONS: Mindfulness and compassion have synergistic and distinct positive effects on ethical sensitivities. Given that both compassion and ethical sensitivities have roots in mindfulness, mindfulness interventions might be one possible venue to enhance these positive aspects of individuals' psychology.

Remote delivery of a Koru Mindfulness intervention for college students during the COVID-19 pandemic.

OBJECTIVE: To examine whether a remote, online, group-based mindfulness intervention results in effects during the COVID-19 pandemic. PARTICIPANTS: 111 college students: 58 in the intervention group, 53 in a waitlist control group. METHODS: Randomized control trial (RCT) using a 4-week Koru Mindfulness program, investigating pre-to-posttest changes in the intervention group compared to time-yoked control participants. RESULTS: Average effect size for all 21 variables measured was 0.48. The intervention produced significant benefits for mindfulness, rumination, worry, mood, stress, anxiety, three out of six aspects of psychological wellbeing (Autonomy, Environmental mastery, Self-acceptance) and physical activity. No significant effect was noted for depression (d = 0.33) or sleep (d = -0.13), and three aspects of psychological wellbeing (Personal growth, Positive relationships, Purpose in life). CONCLUSIONS: A remote, online, group-based mindfulness program yielded benefits on stress, anxiety, and mood in college students, even under the dire circumstances of a pandemic.

Police as threat: The influence of race and the summer of Black Lives Matter on implicit and explicit attitudes towards the police.

Police officers partially rely on implicit and explicit stereotypes in their interactions with the public. We investigated if these attitudes are reciprocated, specifically, if people of color implicitly fear police, and whether the events of the summer of 2020 changed the public's attitudes about police. Seven hundred and fifty-nine college students (235 BIPOC) participated, 373 in 2019, 386 in fall 2020. BIPOC participants more readily implicitly associated police officers with threat; implicit police-as-threat scores increased after the summer of 2020 regardless of race. Explicit attitudes showed the same pattern: BIPOC participants had less favorable attitudes of police; participants in Fall 2020 had less favorable attitudes of police. Implicit attitudes were predicted by race, time, the experience of being treated with (dis)respect, and an emphasis on the binding aspect of morality. Explicit attitudes were predicted by the same variables, as well as specific community variables, the moral foundation of individualizing, and implicit attitudes.

Across-subject correlation between confidence and accuracy: A meta-analysis of the Confidence Database.

If one friend confidently tells us to buy Product A while another friend thinks that Product B is better but is not confident, we may go with the advice of our confident friend. Should we? The relationship between people's confidence and accuracy has been of great interest in many fields, especially in high-stakes situations like eyewitness testimony. However, there is still little consensus about how much we should trust someone's overall confidence level. Here, we examine the across-subject relationship between average accuracy and average confidence in 213 unique datasets from the Confidence Database. This approach allows us to empirically address this issue with unprecedented statistical power and check for the presence of various moderators. We find an across-subject correlation between average accuracy and average confidence of R = .22. Importantly, this relationship is much stronger for memory than for perception tasks ("domain effect"), as well as for confidence scales with fewer points ("granularity effect"). These results show that we should take one's confidence seriously (and perhaps buy Product A) and suggest several factors that moderate the relative consistency of how people make confidence judgments.

Evidence that ageing yields improvements as well as declines across attention and executive functions.

Many but not all cognitive abilities decline during ageing. Some even improve due to lifelong experience. The critical capacities of attention and executive functions have been widely posited to decline. However, these capacities are composed of multiple components, so multifaceted ageing outcomes might be expected. Indeed, prior findings suggest that whereas certain attention/executive functions clearly decline, others do not, with hints that some might even improve. We tested ageing effects on the alerting, orienting and executive (inhibitory) networks posited by Posner and Petersen's influential theory of attention, in a cross-sectional study of a large sample (N = 702) of participants aged 58-98. Linear and nonlinear analyses revealed that whereas the efficiency of the alerting network decreased with age, orienting and executive inhibitory efficiency increased, at least until the mid-to-late 70s. Sensitivity analyses indicated that the patterns were robust. The results suggest variability in age-related changes across attention/executive functions, with some declining while others improve.

Intact circadian rhythm despite cortisol hypersecretion in Alzheimer's disease: A meta-analysis.

Hypersecretion of the glucocorticoid steroid hormone cortisol by individuals with Alzheimer's disease (AD) has been suspected for several decades, during which time dozens of examinations of this phenomenon have been conducted and published. The goals of this investigation were to summarize this sizeable body of literature, test whether participant and methodological characteristics modify the magnitude of the AD-associated basal cortisol hypersecretion, and examine whether cortisol circadian rhythmicity is maintained among individuals with AD. To this end, the present meta-analysis and systematic review examined over 300 comparisons of indices of basal HPA-axis functioning between individuals with AD and cognitively normal older adults. AD was associated with basal cortisol elevations (g = 0.45) but the magnitude of the effect was not systematically impacted by any of the participant characteristics considered or the time-of-day of the cortisol sampling. Further, there was no evidence of group differences among direct indices of circadian rhythmicity such as the cortisol awakening response or the diurnal cortisol slope. These results suggest that basal hypersecretion of cortisol, but not circadian dysrhythmia, is characteristic of individuals with AD. Mechanistically, the observed hypersecretion is consistent with the theorized AD-driven deterioration of the hippocampus and subsequent reduction in hypothalamic-pituitary-adrenal axis inhibition. Further investigation is warranted to elucidate the role and timing of cortisol elevations in the progression of AD.

A systematic review and meta-analysis of individual differences in naturalistic sleep quality and episodic memory performance in young and older adults.

Better sleep quality has been associated with better episodic memory performance in young adults. However, the strength of sleep-memory associations in aging has not been well characterized. It is also unknown whether factors such as sleep measurement method (e.g., polysomnography, actigraphy, self-report), sleep parameters (e.g., slow wave sleep, sleep duration), or memory task characteristics (e.g., verbal, pictorial) impact the strength of sleep-memory associations. Here, we assessed if the aforementioned factors modulate sleep-memory relationships. Across age groups, sleep-memory associations were similar for sleep measurement methods, however, associations were stronger for PSG than self-report. Age group moderated sleep-memory associations for certain sleep parameters. Specifically, young adults demonstrated stronger positive sleep-memory associations for slow wave sleep than the old, while older adults demonstrated stronger negative associations between greater wake after sleep onset and poorer memory performance than the young. Collectively, these data show that young and older adults maintain similar strength in sleep-memory relationships, but age impacts the specific sleep correlates that contribute to these relationships.

Depression and episodic memory across the adult lifespan: A meta-analytic review.

Episodic memory deficits have increasingly been recognized as a cognitive feature of depression. To quantify these deficits and determine how they are moderated by various tasks (e.g., stimulus valence) and participant (e.g., age, depression diagnosis) variables, we conducted a three-level meta-analysis on 995 effect sizes derived from 205 studies with 236 unique comparisons between depressive and control groups on episodic memory measures. Overall, depression was associated with small to moderate deficits in episodic memory, Hedges' g = -0.36, 95% CI [-0.41 to -0.31]. Effects were larger in older age, in diagnosed compared to subthreshold depression, and in those taking medication for depression; effects did not differ between those with current and remitted symptoms. Stimulus valence moderated the effects, such that depression-related deficits were particularly pronounced for positive and neutral stimuli, but not for negative stimuli. Educational attainment served as a sort of protective factor, in that at higher levels of education, depressed group performance was more similar to that of controls. These findings confirm the episodic memory deficits in depression but highlight the important differences in the size of these deficits across a number of task- and participant-related variables. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Depression and Cognitive Control across the Lifespan: a Systematic Review and Meta-Analysis.

Depression has been shown to negatively impact neurocognitive functions, particularly those governed by fronto-subcortical networks, such as executive functions. Converging evidence suggests that depression-related executive dysfunction is greater at older ages, however, this has not been previously confirmed by meta-analysis. We performed a systematic review and meta-analysis, using three-level models, on peer-reviewed studies that examined depression-related differences in cognitive control in healthy community-dwelling individuals of any age. We focused on studies of cognitive control as defined by the National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) framework, which centers on goal-directed behavior, such as goal selection (updating, representations, maintenance), response selection (inhibition or suppression), and performance monitoring. In 16,806 participants aged 7 to 97 across 76 studies, both clinical depression and subthreshold depressive symptoms were associated with cognitive control deficits (Hedges' g = -0.31). This relationship was stronger in study samples with an older mean age. Within studies with a mean age of 39 years or higher, which represents the median age in our analyses, the relationship was stronger in clinical compared to subthreshold depression and in individuals taking antidepressant medication. These findings highlight the importance of clinicians screening for cognitive control dysfunction in patients with depression, particularly in later stages of adulthood.

Multiple identity tracking strategies vary by age: An ERP study.

Top-down modulation underlies our ability to focus attention on task-relevant stimuli and ignore irrelevant distractions. Although age-related differences in neural correlates of top-down modulation have been investigated in multiple studies using variety of tasks (Gazzaley et al., 2005; Störmer et al., 2013), the effect of age on top-down modulation in a multiple identity tracking (MIT) task is still unknown. Thus, we investigated age-related differences in the MIT task by employing event-related potentials (ERPs). Participants tracked ten uniquely colored disks, two of which were randomly designated as targets at the beginning of each trial; the targets moved among four stationary distractors (serving as ERP baseline) and four moving distractors. Each type of stimulus was probed during the trial to capture differential patterns of brain activation. Tracking performance was similar across age groups. ERP data showed that younger adults performed the MIT task by enhancing the unique identities associated with targets relative to distractors through feature-based tracking. Older adults showed a pattern of distractor suppression engaging both location- and feature-based tracking strategies. Thus, our findings suggest that compared to younger adults, older adults engage greater levels of neural activity to achieve the same level of performance. These findings are discussed in light of theories of cognitive aging.

Aging and n-Back Performance: A Meta-Analysis.

OBJECTIVES: To provide a systematic review of age-related differences in n-back performance. METHOD: Meta-analytic data aggregation. RESULTS: Access for items stored within the focus of attention (0-back and 1-back) was very fast and quasi-perfect; when items are held outside the focus (n > 1), an additional cost was accrued in both accuracy and response time. Age-related differences in accuracy conformed to this bifurcation. Longer lists led to larger costs when going from 1-back to 2-back in older adults. For 1-back accuracy, studies that used visual (as opposed to verbal) stimuli, were experimenter-paced, and used shorter list lengths led to larger age-related differences; for 2-back accuracy, a larger difference in chronological age, visual stimuli, and a higher target proportion led to larger age-related differences. For 1-back response times, age-related differences were larger for studies that had a larger chronological age difference, used experimenter pacing, did not contain lures, and used shorter list lengths; for 2-back response times, age-related differences were larger for studies with larger chronological age differences, visual presentation, experimenter pacing, and a higher target proportion. DISCUSSION: The results suggest a specific age-related deficit associated with focus switching within working memory. Evidence for specific executive-control-related explanations, in contrast, is mixed.

Now you feel it, now you don't: Motivated attention to emotional content is modulated by age and task demands.

Several studies with younger adults have examined the degree to which emotion captures attention using the event-related potentials (ERP) technique, but it is unknown whether there are age-related differences on this issue. We examined ERP correlates of age-related differences in processing of task-relevant and task-irrelevant emotional material. Participants viewed emotional or neutral images, presented at fixation, flanked by two bars of either differing or matching orientation. In one set of trials, participants decided whether the pictures were presented in black-and-white or color; in another set of trials, they made a match/judgment on the flanking bars. Before the experiment proper, we determined each individual's threshold for line orientation (in the presence of neutral pictures at fixation); mismatch bar stimuli were constructed using this threshold, thus equating baseline performance on the bar tasks across individuals. When attention was focused on the images, ERPs provided evidence for emotion-based processing in the younger group, regardless of valence; older adults showed more differentiated valence-based processing as reflected by a positivity effect (in line with socioemotional selectivity theory). When the images were task-irrelevant, older adults showed no evidence of emotional processing whatsoever; younger adults showed a pattern of suppression in the form of reduced processing of emotional material relative to neutral images. These findings suggest that, once performance on a neutral baseline task is equated, older adults do not exhibit a specific age-related deficit in inhibiting emotional material; they also suggest qualitative differences in processing of to-be-ignored emotional material in younger and older adults.

Resolving Age-Related Differences in Working Memory: Equating Perception and Attention Makes Older Adults Remember as Well as Younger Adults.

OBJECTIVES: Older adults show clear deficits in working memory functioning. Here, we investigate the often-reported decline in focus switching, that is, the ability to shift items from the focus of attention into working memory, and back. Specifically, we examined whether equating subjects on early processing (perception and attention) might ameliorate the deficit. METHOD: We examined 1-Back and 2-Back performance in younger and older adults, with line segments of different orientation as the stimuli. Stimuli were calibrated depending on each individual's 75% threshold for 1-Back performance. Subjects made match/mismatch judgments. RESULTS: After the calibration on 1-Back performance, no age-related differences were found on either accuracy or sensitivity in the 2-Back task. Additionally, when investigating focus-switch trials versus non-focus-switch trials in a random-order 2-Back task, older adults were more efficient at switching the focus of attention than younger adults. DISCUSSION: These results provide evidence for the view that age-related limitations in focus switching in working memory are caused (at least in part) by changes in early processing (perception and attention), suggesting that (at least some of the) age-related differences in working memory functioning may be due to shifts in trade-off between early processing and memory-related processing.

Retrospective Attention in Short-Term Memory Has a Lasting Effect on Long-Term Memory Across Age.

OBJECTIVES: Declines in both short- and long-term memory are typical of healthy aging. Recent findings suggest that retrodictive attentional cues ("retro-cues") that indicate the location of to-be-probed items in short-term memory (STM) have a lasting impact on long-term memory (LTM) performance in young adults. Whether older adults can also use retro-cues to facilitate both STM and LTM is unknown. METHOD: Young and older adults performed a visual STM task in which spatially informative retro-cues or noninformative neutral-cues were presented during STM maintenance of real-world objects. We tested participants' memory at both STM and LTM delays for objects that were previously cued with retrodictive or neutral-cues during STM order to measure the lasting impact of retrospective attention on LTM. RESULTS: Older adults showed reduced STM and LTM capacity compared to young adults. However, they showed similar magnitude retro-cue memory benefits as young adults at both STM and LTM delays. DISCUSSION: To the best of our knowledge, this is the first study to investigate whether retro-cues in STM facilitate the encoding of objects into LTM such that they are more likely to be subsequently retrieved by older adults. Our results support the idea that retrospective attention can be an effective means by which older adults can improve their STM and LTM performance, even in the context of reduced memory capacity.

Foggy windows: Pupillary responses during task preparation.

We investigated pupil dilation in 96 subjects during task preparation and during a post-trial interval in a visual search task and an auditory working memory task. Completely informative difficulty cues (easy, medium, or hard) were presented right before task preparation to examine whether pupil dilation indicated advance mobilisation of attentional resources; functional magnetic resonance imaging (fMRI) studies have argued for the existence of such task preparation, and the literature shows that pupil dilation tracks attentional effort during task performance. We found, however, little evidence for such task preparation. In the working memory task, pupil size was identical across cues, and although pupil dilation in the visual search task tracked the cue, pupil dilation predicted subsequent performance in neither task. Pupil dilation patterns in the post-trial interval were more consistent with an effect of emotional reactivity. Our findings suggest that the mobilisation of attentional resources in the service of the task does not occur during the preparatory interval, but is delayed until the task itself is initiated.