ABSTRACT
To access for possible hormone dependence, 19 samples of normal salivary gland tissue and 14 samples of salivary gland carcinoma were quantitatively analyzed for estrogen receptor (ER) content. A receptor protein content of greater than or equal to 1 fmol/mg of cytosol protein was considered positive. Ten (77%) of 13 histologically normal samples, and four (80%) of five tumor samples obtained from male patients contained ER by this criterion, as did five (83%) of six normal samples and eight (88%) of nine tumor samples obtained from female patients. Mean ER concentrations plus or minus SE in male-derived samples were 2.02 +/- .42 fmol/mg of cytosol protein for normal tissue and 4.35 +/- 1.5 fmol/mg of cytosol protein for tumor tissue; mean ER concentrations in female-derived samples were 3.48 +/- 1.1 fmol/mg of cytosol protein for normal tissue and 12.64 +/- 6.4 fmol/mg of cytosol protein for tumor tissue. Four of eight tumors in women had levels considered to be "hormonally dependent" in breast carcinoma. These findings indicate that salivary gland carcinomas may be hormone-dependent.
Subject(s)
Adenocarcinoma/analysis , Adenoma/analysis , Parotid Neoplasms/analysis , Receptors, Estrogen/analysis , Salivary Gland Neoplasms/analysis , Salivary Glands/analysis , Submandibular Gland Neoplasms/analysis , Adult , Aged , Female , Humans , Male , Middle AgedABSTRACT
Instillation of progesterone into the vaginal lumen of BALB/c mice treated neonatally with 25 micrograms 17 beta-estradiol resulted in a significant decrease in vaginal concretions (P less than 0.025), vaginal cornification (P less than 0.025) and vaginal lesions (P less than 0.05).