Colonoscopy Findings of Uncomplicated Enteric Fever Mimicking Koch's Disease.

Enteric fever is a common occurrence in Southeast Asia with a myriad of presentations. Partial treatment often leads to prolonged illness. Along with this, bowel imaging often confounds the picture with tuberculosis. Colonoscopy and biopsy may help to differentiate from tuberculosis. The data on colonoscopy is scarce in enteric fever and is mostly available from case reports of gastrointestinal (GI) bleeding. We have described three cases of enteric fever with GI involvement mimicking tuberculosis. The colonoscopy picture is characteristic of pinkish-bluish ileal mucosa, with edema and decreased distensibility, along with multiple superficial ulcers. The ileocecal valve was involved in all three cases. The ascending colon was involved in two cases. There was complete resolution of lesions after treatment on follow-up. How to cite this article: Verma A, Dahale AS, Gopal P, et al. Colonoscopy Findings of Uncomplicated Enteric Fever Mimicking Koch's Disease. Euroasian J Hepato-Gastroenterol 2024;14(1):120-123.

Chromophore appended DPA-based copper(II) complexes with a diimine motif towards DNA binding and fragmentation studies.

Mixed ligand copper(II) complexes [Cu(L1)(bpy)](ClO4)21 and [Cu(L2)(bpy)](ClO4)22 (where L1 = 1-(anthracen-9-yl)-N,N-bis(pyridin-2-ylmethyl)methanamine, L2 = 1-(pyren-1-yl)-N,N-bis(pyridin-2-ylmethyl)methanamine and bpy = 2,2'-bipyridine) were synthesised and characterised thoroughly via different analytical and spectroscopic techniques i.e., UV-vis spectroscopy, fluorescence spectroscopy, FT-IR spectroscopy, HRMS and EPR spectroscopy. The molecular structures of the synthesised complexes were obtained using the single-crystal X-ray diffraction technique. Both complexes exhibited penta-coordinated and acquired distorted square pyramidal geometry. The redox behaviour of complexes 1 and 2 was investigated by employing cyclic voltammetry. The DNA binding study was carried out by UV-vis spectrophotometry using double-stranded salmon sperm DNA (ds-ss-DNA). The binding constant (Kb) values of 1 and 2 were 0.11 × 104 M-1 and 1.05 × 104 M-1, respectively, which indicates that 2 has better binding ability than 1. This might be due to the higher conjugative abilities with the extended surface area of the aromatic pyrene ring compared to the anthracene moiety. The fluorescence quenching experiments were also performed with EB bound DNA (EB-DNA) and Stern-Volmer constant (KSV) values were calculated as 1.23 × 105 M-1 and 1.39 × 105 M-1 for 1 and 2, respectively, suggesting that 2 showed stronger interaction with ss-DNA than 1. The molecular docking data support the DNA-binding studies, with the sites and mode of interactions against B-DNA varying with 1 and 2. Evaluation of the DNA binding properties of the complexes to linearized plasmid DNA indicated that 2 had modest DNA binding properties, which is a pre-requisite for a genotoxic agent. The effect of 1 and 2 on cell survival was analysed using HeLa cells by MTT assay and it was observed that the IC50 values of 1 and 2 were 43.7 µM and 18.6 µM, respectively. Our study paves the way for the designing of bio-inspired novel mixed metal complexes, which shows promising results for further exploration of molecular and mechanistic studies towards the development of non-platinum based economical metallodrugs.

Environmental effects of ICT diffusion, energy consumption, financial development, and globalization: panel evidence from SAARC economies.

The rising energy demand for information and communication technology (ICT) devices has piqued the interest of scholars and policymakers. Given that ICT devices are ubiquitous, any attempt to mitigate climate change should address the carbon footprint of the ICT sector. The present study examines the direct impact of ICT on the environment and the indirect impact through interaction with energy consumption, financial development, and globalization in SAARC economies from 2000 to 2020. Using econometric approaches robust to cross-sectional dependence, such as the Driscoll-Kraay estimator and the Dumitrescu-Hurlin causality test, the study found that ICT, renewable energy consumption, and globalization significantly reduce CO2 emission, whereas non-renewable energy consumption and financial development significantly increase emission. However, the interaction between financial development and ICT jointly reduces CO2 emissions. Similarly, renewable energy and globalization reduce emissions from increased ICT usage. The study also confirms the validity of the environmental Kuznets curve hypothesis for ICT diffusion. The causality test indicates bidirectional causality between ICT and CO2 emissions. Results suggest that SAARC economies can safely boost ICT and related applications to minimize emissions. They should also use renewable energy and green innovations in telecommunications to reduce their adverse environmental repercussions.

The role of ICT diffusion in sustainable human development: an empirical analysis from SAARC economies.

This study intends to examine the impact of ICT diffusion, globalization, financial development, government effectiveness, and economic growth on sustainable human development (SHD) (i.e., the development of human capital adjusted against the human ecological footprint) using 2005-2020 panel data of SAARC economies. The methodology involves econometric techniques robust to cross-sectional dependence (CSD), such as Pesaran CSD tests; second-generation unit root tests; Pedroni, Kao, and Westerlund cointegration tests; FMOLS, DCCE-MG, and Driscoll-Kraay (DK) regressions; and DH causality tests. The findings of the cointegration tests demonstrate that the variables are cointegrated and have a long-run equilibrium relationship. The results from the DCCE-MG and DK regressions indicate that ICT diffusion has a significant favorable impact on SHD. Similarly, globalization and economic growth also have a significant positive impact on SHD. On the other hand, the impact of government effectiveness and financial development was found to be insignificant. In addition, the DH causality test results show the presence of a unidirectional causality running from ICT diffusion to SHD and globalization to SHD. A bidirectional causal link is detected between economic growth and SHD. Therefore, the study concludes that in order to resolve the undesirable consequences of environmental degradation on human development in the globalized era, it is essential for SAARC economies to tackle the challenges of adequate ICT infrastructure: particularly, access and affordability. By eliminating these significant barriers to ICT access, CO2 emissions can be reduced, and human development can be sustained simultaneously.