The importance of gut-brain axis and use of probiotics as a treatment strategy for multiple sclerosis.

It has been shown that the dysbiosis of the gut's microbes substantially impacts CNS illnesses, including Alzheimer's, Parkinson's, autism, and autoimmune diseases like multiple sclerosis (MS). MS is a CNS-affected autoimmune demyelination condition. Through a two-way communication pathway known as the gut-brain axis, gut microbes communicate with the CNS. When there is a disruption in the gut microbiome, cytokines and other immune cells are secreted, which affects the BBB and gastrointestinal permeability. Recent research using animal models has revealed that the gut microbiota may greatly influence the pathophysiology of EAE/MS. Any change in the gut might increase inflammatory cytokinesand affect the quantity of SCFAs, and other metabolites that cause neuroinflammation and demyelination. In- vivo and in-vitro studies have concluded that probiotics affect the immune system and can be utilized to treat gastrointestinal dysbiosis. Any alteration in the gut microbial composition caused by probiotic intake may serve as a preventive and treatment strategy for MS. The major goal of this review is to emphasize an overview of recent research on the function of gut microbiota in the onset of MS and how probiotics have a substantial impact on gastrointestinal disruption in MS and other neuro disorders. It will be easier to develop new therapeutic approaches, particularly probiotic-based supplements, for treating multiple sclerosis (MS) if we know the link between the gut and CNS.

Importance of Zebrafish as an Efficient Research Model for the Screening of Novel Therapeutics in Neurological Disorders.

Over the previous years, the use of an animal model has become very common for the screening of novel drugs. Animal model represents the complex problems of humans into the simplest forms, so these can be extended further to be included in the experimental procedure. The most successful models in neuroscience, rats and mice, are undoubtedly considered as one of the best models to understand the psychology of the mammalian brain and its associated functions involved in behavioral repertoire. Moreover, recently researchers in behavioral neuroscience are focusing more on the use of aquatic animals, especially fish, as model species due to their simplicity and cost-effectiveness. Zebrafish (Danio rerio) is a tropical fish from the minnow family, a genetic structure surprisingly 84% similar to humans. It is gaining popularity as a model to study the mechanism in behavioral neuropharmacology. Moreover, zebrafish has numerous advantages over other rodent models like the ease in maintenance due to their small size, more breeding power, transparency of embryos, overall reduced cost of experimentation, and many more. Nowadays, it is considered an ideal model to study the neurobehavioral aspects with relevance to humans. It is also used in a variety of scientific studies like genetics, neuroscience, pharmacology, and toxicology. In this manuscript, we have described the feasibility and importance of zebrafish as a model for the screening of novel drugs for different neurological disorders.

Synthesis of carbon nanotubes via chemical vapor deposition: an advanced application in the Management of Electroplating Effluent.

Iron catalyst supported over magnesium oxide had been synthesized with different percentages of Fe, i.e., 0.5, 1, and 5% employing the method of impregnation. These fabricated catalysts were used to grow carbon nanotubes (CNTs) using a chemical vapor deposition (CVD) method in the CVD reactor. The 5% Fe/MgO catalyst showed the maximum growth of CNTs. The synthesized novel CNTs (5Fe-CNTs) were investigated for their adsorption capabilities for the removal of parts per million levels of hexavalent chromium from electroplating effluent. The 5Fe-CNTs were characterized by field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Raman spectroscopy, thermogravimetric analysis (TGA), and Zeta analyzer. The 5Fe-CNTs showed remarkable adsorption capacity of 63.3 mg g-1 toward Cr(VI) in water. The effects of various operating conditions on the removal of Cr(VI) from wastewater have been evaluated. Kinetic and thermodynamic studies were performed, and it was observed that the experimental data is in best agreement with pseudo-second-order kinetics. Besides the synthesized CNTs exhibited good recyclability for adsorbing Cr(VI) as even after 3 adsorption cycles, the adsorption capacity was reduced by less than 10%.

Magnetic magnesium ferrite-doped multi-walled carbon nanotubes: an advanced treatment of chromium-containing wastewater.

Magnetic magnesium ferrite (MgFe2O4) nanoparticles (MMFNPs) were synthesized by employing the sol-gel method. These nanoparticles were ultrasonically decorated onto the multi-walled carbon nanotubes (MWCNTs) to produce magnetic magnesium ferrite nanocomposites (MMFNCs). The as-prepared materials were investigated for their capability to treat wastewater loaded with heavy metals. The synthesized nanocomposites were characterized by field emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Fourier transmission infrared spectroscopy, Raman spectroscopy, thermogravimetric analysis, and zeta analyzer. Besides, the effect of the environmental chemistry of the solution was determined by varying the critical parameters. The adsorption isotherm of Cr(VI) adsorption onto the as-synthesized MMFNC best fitted the Langmuir adsorption isotherm model. The high adsorption capacity of 175.43 mg/g was achieved at a temperature of 40 °C under optimized conditions. Due to the magnetic nature of MMFNC, they are easily recoverable from the aqueous solution making them cost-friendly. Even after seven consecutive adsorption-desorption cycles, the MMFNC presented an efficiency loss of less than 20% for the removal of Cr(VI) ions. The presented development method offers prospects in developing a highly effective magnetic adsorbent for heavy metal removal from wastewater.