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Scand J Gastroenterol ; 14(3): 327-31, 1979.
Article in English | MEDLINE | ID: mdl-375375

ABSTRACT

Antral somatostatin- and gastrin-producing cells (D and G cells) were studied in a group of patients with chronic renal failure (CRF) in comparison with a control group. Gastric acid secretion and serum gastrin, phosphate, and parathormone (PTH) levels were also evaluated in every patient. The group with CRF showed a mild increase both in G- and in D-cell denisty. In this group serum phosphate and PTH levels were higher than normal, showing hyperparathyroidism in every patient. A direct correlation was found between G-cell density and parathyroid function in patients with CRF. Hyperparathyroidism, therefore, seems to play a role in the mechanism of increased serum gastrin levels in CRF.


Subject(s)
Kidney Failure, Chronic/pathology , Pyloric Antrum/pathology , Adult , Cell Count , Female , Fluorescent Antibody Technique , Gastric Juice/metabolism , Gastrins/blood , Humans , Hyperparathyroidism/diagnosis , Hyperparathyroidism/etiology , Kidney Failure, Chronic/blood , Kidney Failure, Chronic/physiopathology , Male , Middle Aged , Parathyroid Glands/physiopathology , Parathyroid Hormone/blood , Pentagastrin , Phosphates/blood
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