ABSTRACT
Water suspensions of titanium dioxide nanoparticles were introduced intragastrically to growing male Wistar rats daily for 28 days. The data obtained revealed the presence of toxic risks related to said nanomaterials action and demonstrate the necessity of sanitary regulation of titanium dioxide nanoparticles used in food contact materials, cosmetics and other commodity.
Subject(s)
DNA Damage , Intestinal Absorption/drug effects , Intestine, Small/metabolism , Nanoparticles/toxicity , Titanium/toxicity , Administration, Oral , Animals , Blood Cell Count , Body Weight/drug effects , Crystallization , Hemoglobins/analysis , Intestine, Small/drug effects , Liver/drug effects , Liver/enzymology , Liver/metabolism , Liver Function Tests , Male , Nanoparticles/ultrastructure , Particle Size , Rats , Rats, Wistar , Sulfhydryl Compounds/metabolism , Titanium/chemistry , Titanium/pharmacokinetics , Toxicity Tests, ChronicABSTRACT
Intestinal microbiocenosis condition, cytokine IL-6, IL-10 and TNF-alpha levels and allergic sensitivity in experimental systemic anaphylaxis test were studied in rats that received intragastrically nanoparticles of titanium dioxide. The results obtained were discussed from the standpoint of possible health risks related to nanodimensional titanium dioxide exposure.
Subject(s)
Anaphylaxis/metabolism , Cecum/metabolism , Cecum/microbiology , Cytokines/metabolism , Nanoparticles , Titanium , Anaphylaxis/chemically induced , Animals , Male , Nanoparticles/administration & dosage , Nanoparticles/adverse effects , Rats , Rats, Wistar , Titanium/administration & dosage , Titanium/adverse effectsABSTRACT
Presented article is a review of the modern data on nanotechnology use in food manufacturing. There are discussed the basic scopes of nanotechnology application in food industry. One of the main problems arising in connection with introduction of nanotechnology in food, is an absence of reliable methods of identification and the control of nanoparticles is in structure of foodstuff including the control of their authenticity. Other problem is connected to necessity of an estimation of the risks connected to presence of potentially toxic nanoparticles in food. The analysis of foreign experience of researches in the given area allows to formulate methodological approaches to formation of domestic system of nanosafety.
Subject(s)
Food Industry/methods , Nanostructures/adverse effects , Nanostructures/standards , Nanotechnology , Food Industry/standards , Food Industry/trends , Quality ControlABSTRACT
Nowdays nanotechnology obtains wide use of in industry and agriculture. One of the most perspective and widespread nanomaterials is nanosilver. In this article we focused on the prospects and advantages of the following nanomaterial and also described the risks for humanity and environment.
