[Flocculant interaction with native antibiotic solutions. The effect of flocculants on the quality indices of native solutions as dependent on a number of factors]. / Izuchenie vzaimodeistviia flokkuliantov s nativnymi rastvorami antibiotikov. Vliianie flokkuliantov na pokazateli kachestva nativnykh rastvorov v zavisimosti ot riada faktorov.

Flocculants had a significant effect on the characteristics of the fermentation broth filtrates of some antibiotics. They decreased the filtrate turbidity, concentration of the organic ballast, etc. The size of the floccules depended on a number of factors, including the fluocculant concentration, agitation rate, concentration of the dispersing phase in the initial filtrate. The optimal concentration of the flocculant was defined not only by the type of the antibiotic-producing organism but also by composition of the nutrient medium used for the biosynthesis. Floccculant treatment provided a significant increase in the quality of the fermentation broth filtrates with respect to the main parameters: levels of proteins, pigments, emulgation capacity.

[Flocculant interaction with native antibiotic solutions. An examination of the mechanism of the process]. / Izuchenie vzaimodeistviia flokkuliantov s nativymi rastvorami antibiotikov. Rassmotrenie mekhanizma protsessa.

Some characteristics of the fermentation broth filtrates, i.e. concentration of the disperse particles and some of their parameters (projected length, area, distribution of the particles along the maximum chord) were determined and estimated after flocculation. It was shown that the floccules were mainly formed as fine colloid admixtures present not only in "turbid", but also in visually transparant solutions. It was found that the mechanism of flocculation was rather complicated and not always similar for different batches of the fermentation broth filtrate: it was, in particular, affected by the electrostatic interactions, the flocculant interaction with inorganic reagents, bridge-forming processes.

[Use of a rotation chart for studying the flocculation of admixtures in native solutions]. / Primenenie rotatabil'nogo planirovaniia éksperimenta dlia izucheniia flokkuliatsii primesei v nativnykh rastvorakh

The process of admixture flocculation in fermentation broth filtrates of penicillin was studied experimentally according to the schemes of rotatabel planning of the 2nd order. Equations describing the effect of the main factors on the process were worked out and the main effects of the pair interactions were found.