1.
J Chemother
; 1(4 Suppl): 981-4, 1989 Jul.
Article
in English
| MEDLINE
| ID: mdl-16312733
Subject(s)
Anti-Bacterial Agents/therapeutic use , Cefotetan/therapeutic use , Digestive System Surgical Procedures/adverse effects , Elective Surgical Procedures/adverse effects , Surgical Wound Infection/prevention & control , Antibiotic Prophylaxis , Controlled Clinical Trials as Topic , Digestive System Surgical Procedures/classification , Humans , Postoperative Complications/prevention & control , Urinary Tract Infections/prevention & control
2.
Chemioterapia
; 7(4): 218-22, 1988 Aug.
Article
in English
| MEDLINE
| ID: mdl-3180299
ABSTRACT
Single dose cefotetan was compared with either a combination of metronidazole and cefazolin given for 24 hours or 3 doses of cefuroxime as prophylaxis in elective abdominal surgery. Wound infections and infections at remote sites (UTI and RTI) were similar in all groups. In a third group prophylaxis of abdominal surgery using a single 2g dose of cefotetan was compared to 2 doses of the same drug, given 12 hours apart. There was no demonstrable advantage to giving 2 doses. The low incidence of post-operative infections seen in all groups indicates the efficacy of cefotetan in the surgical prophylaxis of elective abdominal surgery.
