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3.
Eur J Med Genet ; 52(4): 229-33, 2009.
Article in English | MEDLINE | ID: mdl-19401242

ABSTRACT

Leukonychia is an ungueal discoloration or dyschromia. The hereditary form is rare. In the observations reported in the literature, leukonychia was total or sub-total, and was sometimes associated to other various symptoms. We report an original observation of hereditary leukonychia totalis in a father and two of his children, associated with acanthosis-nigricans-like lesions and hair dysplasia. These symptoms were also present in eight other members of the same family.


Subject(s)
Acanthosis Nigricans/complications , Hair/abnormalities , Nail Diseases/genetics , Acanthosis Nigricans/pathology , Child , Fathers , Female , Genes, Dominant , Hair/ultrastructure , Humans , Male , Nuclear Family , Pedigree , Syndrome
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