ABSTRACT
The prevalence of psychological disorders in patients with common skin diseases was assessed in a large representative sample of the French adult population. General health, as measured by the EQ5D score, was significantly lower if patients reported having rosacea, atopic dermatitis, urticaria, fungal infections, psoriasis or acne. The proportions of participants reporting being extremely anxious or depressed were higher in those who reported having rosacea, atopic dermatitis or contact dermatitis. Difficulties in sexual and conjugal life were frequently reported by people with psoriasis, atopic dermatitis, contact dermatitis, urticaria and, in particular, acne. Sleep disorders were present in 30-50% of those who reported having acne, rosacea, eczema, psoriasis or urticaria. Sleep disorders may be related not only to pruritus, but also to disfiguring skin diseases. Anxiety and depression complications were mainly reported by those with disfiguring diseases. Sexual and conjugal dysfunctions were associated with all dermatoses (with the exception of warts).
Subject(s)
Dermatitis, Atopic , Eczema , Psoriasis , Skin Diseases , Urticaria , Adult , Humans , Psoriasis/diagnosis , Psoriasis/epidemiology , Skin Diseases/diagnosis , Skin Diseases/epidemiologySubject(s)
Edema/chemically induced , Granuloma, Foreign-Body/chemically induced , Mineral Oil/adverse effects , Penile Diseases/chemically induced , Skin Ulcer/chemically induced , Administration, Topical , Adult , Anti-Inflammatory Agents/administration & dosage , Colloids/administration & dosage , Edema/drug therapy , Edema/pathology , Gels , Granuloma, Foreign-Body/drug therapy , Granuloma, Foreign-Body/pathology , Humans , Injections, Intralesional , Injections, Subcutaneous , Male , Mineral Oil/administration & dosage , Penile Diseases/drug therapy , Penile Diseases/pathology , Skin Ulcer/drug therapy , Skin Ulcer/pathology , Treatment Outcome , Triamcinolone Acetonide/administration & dosageABSTRACT
BACKGROUND: A 72-year-old man presented with a Merkel cell carcinoma (MCC) of the left cheek with concomitant nodal spread. A 61-year-old man presented with an MCC of the right thigh with rapid nodal recurrence. INVESTIGATIONS: Skin biopsy samples proved the MCC nature of the neoplasm in both patients. Staging procedure included clinical and radiological investigations. DIAGNOSIS: Advanced stage II MCC. MANAGEMENT: Neoadjuvant cisplatin, etoposide and cyclophosphamide (EPC) regimen led to local control in the first patient and allowed curative surgery associated with adjuvant radiation therapy. Complete remission was maintained for 32 months. The second patient was treated by surgery plus radiation therapy. Nodal and cutaneous recurrences were treated with a neoadjuvant EPC regimen leading to a 5-year complete remission.
