ABSTRACT
The development of pre-clinical toxicological expertise of medicaments in Russia is accompanied of improvement in research and expertise methods, inculcation of international standards. The main principles of expertise were development: experts' competency and objectivity; experts' independence in realization their procurations and noninterference of persons who represent interest of the expertise client in experts' actions; abidance by lawfulness in expertise procedures; fullness of expertise, corresponding to state-of-the-art world level of scientific, technical and technological knowledge subject to normative legal documents regulating pharmacotoxicological examinations performance; systematization of expert scientific analysis; abidance by principles of biomedical ethics; uniqueness of each medicament; service to interests of patient and of community health protection.
Subject(s)
Biomedical Research/organization & administration , Drug Evaluation, Preclinical/standards , Drug-Related Side Effects and Adverse Reactions/diagnosis , Animals , Humans , RussiaSubject(s)
Anti-Bacterial Agents/toxicity , Animals , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/standards , Cefazolin/administration & dosage , Cefazolin/standards , Cefazolin/toxicity , Cefoperazone/administration & dosage , Cefoperazone/standards , Cefoperazone/toxicity , Ceftriaxone/administration & dosage , Ceftriaxone/standards , Ceftriaxone/toxicity , Drug Contamination , Lethal Dose 50 , Mice , Pharmacopoeias as Topic , Toxicity Tests, AcuteABSTRACT
The toxicology of an original Soviet antidepressant inkasan-3-methyl-8-methoxy-3H, 1,2,5,6-tetrahydropyrazino [1,2,3-ab] beta-carboline hydrochloride was studied in different types of experimental animals (mice, rats, rabbits, dogs). It was established that the drug is less toxic than imipramine. The toxic manifestations (seizures, stereotypy) seen in dogs receiving high doses of inkasan for a long time are likely to be linked with a stimulating component that characterizes the drug action on the central nervous system.
Subject(s)
Antidepressive Agents/toxicity , Carbolines/toxicity , Animals , Antidepressive Agents/poisoning , Blood Cells/drug effects , Blood Glucose/analysis , Carbolines/poisoning , Dogs , Dose-Response Relationship, Drug , Drug Synergism , Epinephrine/toxicity , Female , Imipramine/toxicity , Lethal Dose 50 , Male , Mice , Rabbits , Rats , Time FactorsABSTRACT
It has been demonstrated in different species of experimental animals (mice, rats, cats, dogs) that the Soviet drug pyrazidol is a little toxic drug. Prolonged repeated administration of pyrazidol does not exert any damaging action on the vitally important organs and systems of the body. Pyrazidol is less toxic than imipramine.
