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1.
Int J Oral Maxillofac Surg ; 52(4): 413-416, 2023 Apr.
Article in English | MEDLINE | ID: mdl-36008220

ABSTRACT

Osseointegrated dental implants in the vicinity of oral squamous cell carcinoma (OSCC) will become more common given the increasing popularity of dental implants. Reports and studies of OSCC around dental implants are rare, as is the topic of how to handle OSCC surgically when implants are in contact with the tumour. In view of this uncertainty, a histological study was performed to assess tumour behaviour around implants. The aim was to determine whether an implant facilitates inward growth of the tumour and how this should be taken into account during staging and treatment planning. A total of 20 specimens were collected. The implants were macroscopically in contact with OSCC in 13 of the 20 specimens. Histologically, tumour tissue near the implant was indeed confirmed in nine of these cases. In seven cases, tumour invasion had led to resorption of the underlying jaw bone; tumour between the bone-implant interface was identified in only two of these cases, but without downward growth along the implant. In conclusion, no proof was found to confirm that the bone-implant interface is a preferred route for invasion. Therefore, dental implants in the vicinity of OSCC should not influence staging and treatment planning in this regard.


Subject(s)
Alveolar Bone Loss , Carcinoma, Squamous Cell , Dental Implants , Head and Neck Neoplasms , Mouth Neoplasms , Humans , Squamous Cell Carcinoma of Head and Neck , Dental Implantation, Endosseous
2.
Lasers Med Sci ; 32(9): 1965-1970, 2017 Dec.
Article in English | MEDLINE | ID: mdl-28782092

ABSTRACT

This study is to investigate the efficacy of different irrigant activation techniques on removal of accumulated hard tissue debris (AHTD) in mesial roots of human mandibular molars. Extracted human mandibular molars with an isthmus between the mesial root canals were selected based on micro-CT (µCT) scans. The mesial canals were instrumented to an apical diameter ISO30 using ProTaper rotary files. Teeth were randomly assigned to three irrigant activation groups (n = 10): ultrasonically activated irrigation (UAI) using a size 20 Irrisafe for 3 × 20 s, laser-activated irrigation (LAI) with an Er:YAG laser (2940 nm) and plain 300 µm fiber tip inside the canal (20 mJ, 20 Hz, 3 × 20 s), and laser-activated irrigation with identical parameters with a 400 µm photon-induced photoacoustic streaming (PIPS) tip held at the canal entrance. All teeth were scanned with µCT before and after instrumentation and after irrigant activation. After reconstruction and image processing, the canal system volume filled with hard tissue debris before and after irrigant activation was calculated. Changes in hard tissue debris volumes were compared between groups using one-way ANOVA. The percentage volume of hard tissue debris (vol%) was significantly lower after irrigant activation in all groups. Although the lowest debris values were observed in the laser groups, no significant differences in the vol% of accumulated hard tissue debris after activation were observed between groups. Accumulated hard tissue debris was reduced significantly in all activation groups. Ultrasonically and laser-activated irrigation regimens performed similarly in this respect. None of the tested methods was able to render the root canal systems free of debris.


Subject(s)
Dental Pulp Cavity/radiation effects , Lasers, Solid-State , Mandible/radiation effects , Molar/radiation effects , Root Canal Irrigants/pharmacology , Ultrasonics , X-Ray Microtomography/methods , Humans , Imaging, Three-Dimensional
3.
Ned Tijdschr Geneeskd ; 152(4): 207-12, 2008 Jan 26.
Article in Dutch | MEDLINE | ID: mdl-18320947

ABSTRACT

OBJECTIVE: Descriptive study of the development of children 5 years after neonatal extracorporeal membrane oxygenation (ECMO). DESIGN: Descriptive. METHOD: 98 treated children were subjected to a paediatric, neurological, psychological, physiotherapeutic and logopaedic examination. The children came from 2 Dutch ECMO-centres (the Erasmus MC-Sophia Children's Hospital in Rotterdam and the University Medical Centre St Radboud in Nijmegen, The Netherlands). RESULTS: Neurological disorders were found in 17 of the 98 investigated children, and in 6 cases these were serious. Among the remaining 92 children, 24 had motor disorders and 11 had delayed cognitive development. The average IQ (100.5) was within the normal range. CONCLUSION: A significant proportion ofthe children that had been treated with ECMO had long-term morbidity in the form of neurological defects and developmental disorders.


Subject(s)
Developmental Disabilities/epidemiology , Extracorporeal Membrane Oxygenation/adverse effects , Nervous System Diseases/epidemiology , Child, Preschool , Female , Follow-Up Studies , Humans , Infant, Newborn , Male , Netherlands/epidemiology , Prevalence , Severity of Illness Index
4.
Eur Respir J ; 9(8): 1757-9, 1996 Aug.
Article in English | MEDLINE | ID: mdl-8866607

ABSTRACT

A 57 year old man, receiving compensation for talc pneumoconiosis since 1977, was admitted to hospital for the first time in 1987, with symptoms of weight loss, fever, dyspnoea and productive cough. A chest roentgenogram showed bilateral cavitation. Two years later, Mycobacterium xenopi was found in sputum cultures. Despite specific oral antibiotherapy, the patient's health deteriorated and he died in 1990. To the best of our knowledge, this is the first reported case of an association of talcosis with a M. xenopi pneumonia. The relative timing of the two diseases suggests that talc pneumoconiosis predisposed to the infection by M. xenopi.


Subject(s)
Fungemia/diagnosis , Mycobacterium Infections, Nontuberculous/diagnosis , Pneumoconiosis/diagnosis , Talc/adverse effects , Diagnosis, Differential , Disease Progression , Fatal Outcome , Fungemia/complications , Fungemia/diagnostic imaging , Humans , Male , Middle Aged , Mycobacterium Infections, Nontuberculous/complications , Mycobacterium Infections, Nontuberculous/diagnostic imaging , Pneumoconiosis/complications , Pneumoconiosis/diagnostic imaging , Radiography
6.
Ann Allergy ; 58(6): 416-20, 1987 Jun.
Article in English | MEDLINE | ID: mdl-3592311

ABSTRACT

Three different immunotherapy regimens were given during 4 years to 60 randomized patients. One can conclude from the symptom and medication scores that a tyrosine-bound mixture is less active. The results obtained with mixed grass and with highly purified timothy pollen are comparable, but in favour of the latter.


Subject(s)
Desensitization, Immunologic/methods , Rhinitis, Allergic, Seasonal/therapy , Dose-Response Relationship, Immunologic , Evaluation Studies as Topic , Female , Humans , Male , Pollen/analysis , Pollen/immunology , Skin Tests , Time Factors
9.
Acta Cardiol ; 35(1): 55-61, 1980.
Article in English | MEDLINE | ID: mdl-6967669

ABSTRACT

An internal mammary to pulmonary artery fistula was diagnosed in a patient with a continuous machinery-like murmur over the right upper chest wall 23 years after she was treated for pulmonary tuberculosis.


Subject(s)
Fistula/etiology , Mammary Arteries , Pulmonary Artery , Thoracic Arteries , Tuberculosis, Pulmonary/complications , Adult , Female , Fistula/diagnostic imaging , Humans , Radiography
14.
Clin Allergy ; 8(5): 435-43, 1978 Sep.
Article in English | MEDLINE | ID: mdl-101317

ABSTRACT

Hyposensitization therapy gave a subjective improvement in 84% of grass pollen-sensitive patients receiving an eighteen dose course of aqueous pollen extract (SDV) and in 69% of patients receiving a three dose course of glutaraldehyde-treated pollentyrosine adsorbate (Pollinex). Systemic reactions to treatment were considerably more frequent with the aqueous course, but virtually absent with the short adsorbate course, which seems therefore more convenient for the patient. The SDV treatment induced a more pronounced IgG antibody response both in patients and in guinea-pigs receiving the clinical dosage schedule. The Pollinex treatment showed a tendency to enhance the IgE antibody response in new patients.


Subject(s)
Antigen-Antibody Complex/therapeutic use , Immunosorbents/therapeutic use , Plant Extracts/therapeutic use , Poaceae , Pollen , Rhinitis, Allergic, Seasonal/drug therapy , Adult , Animals , Female , Glutaral/pharmacology , Guinea Pigs , Humans , Immunoglobulin E/biosynthesis , Immunoglobulin G/biosynthesis , Male , Tyrosine
16.
Rev Inst Hyg Mines (Hasselt) ; 33(4): 200-3, 1978.
Article in Dutch | MEDLINE | ID: mdl-552144

ABSTRACT

In a single blind cross-over study 12 patients with asthma received in randomised order aerosols of pirbuterol 400 micrograms, salbutamol 200 micrograms or placebo. Only 9 patients met the criteria and were taken into account for the statistical analysis, namely a stable reversible broncho-obstruction. Pirbuterol and salbutamol did induce a considerable bronchodilation. Both drugs had a similar activity and few side effects.


Subject(s)
Albuterol/administration & dosage , Asthma/drug therapy , Bronchodilator Agents/administration & dosage , Ethanolamines/administration & dosage , Adult , Aerosols , Aged , Evaluation Studies as Topic , Female , Humans , Male , Middle Aged , Placebos
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