ABSTRACT
YouTube.com is a popular, free video platform that parents are increasingly using for medical information. This analysis of pediatric strabismus surgery videos found that many videos lack useful information, and some provide disinformation that may be harmful to pediatric eye care.
Subject(s)
Strabismus , Child , Humans , Parents , Social Media , Video RecordingABSTRACT
In head and neck squamous cell carcinoma, immune checkpoint inhibitors (ICI) lead to improved outcomes. There has been reports of accelerated disease progression, or hyperprogression, after ICI initiation. We present a case of hyperprogression after one dose of nivolumab in maxillary sinus squamous cell carcinoma. The patient had complete vision loss due to disease progression into the orbit, as well as intracranial invasion, lytic metastases, and new widespread distal metastases. Hyperprogression can occur after the first dose of immunotherapy. Absent biomarkers regarding individual risk of hyperprogression, caution should be exercised in using ICI in sinonasal cancers with orbital abutting disease. Laryngoscope, 130:907-910, 2020.
Subject(s)
Antineoplastic Agents, Immunological/adverse effects , Carcinoma, Squamous Cell/drug therapy , Carcinoma, Squamous Cell/pathology , Nivolumab/adverse effects , Paranasal Sinus Neoplasms/drug therapy , Paranasal Sinus Neoplasms/pathology , Carcinoma, Squamous Cell/surgery , Disease Progression , Female , Humans , Middle Aged , Paranasal Sinus Neoplasms/surgerySubject(s)
Antibodies, Bispecific/therapeutic use , Antineoplastic Agents/therapeutic use , Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative/therapy , Leukemic Infiltration/therapy , Optic Nerve/drug effects , Optic Nerve/radiation effects , Radiotherapy , Combined Modality Therapy , Humans , Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative/drug therapy , Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative/pathology , Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative/radiotherapy , Leukemic Infiltration/drug therapy , Leukemic Infiltration/pathology , Leukemic Infiltration/radiotherapy , Male , Middle Aged , Optic Nerve/pathology , Visual Acuity/physiologyABSTRACT
BACKGROUND AND OBJECTIVE: To determine the feasibility of attaching human amniotic membrane (HAM), pre-cultured with limbal stem cells (LSCs), to cornea using a novel, light-activated tissue bonding method. MATERIALS AND METHODS: LSCs were isolated from rabbit eyes, and then cultured on de-epithelialized HAM to create grafts (HAM/LSC). These were then transplanted onto rabbit eyes with surgically created limbal stem cell deficiency (LSCD). The grafts were secured either by sutures or by a light-activated method called photochemical tissue bonding (PTB). Outcomes included corneal opacity, inflammation, neovascularization, and collagen alignment. RESULTS: The isolated and cultured cells were verified to be LSCs based on their K19+/intergrin ß1+/P63+/K3 profile. Securing the HAM/LSC graft with PTB provided better outcomes. At 28 days post-surgery, the corneal opacity scores were significantly lower after securing the graft with PTB compared with suture attachment (0.8 ± 0.5 vs. 1.8 ± 0.5, P < 0.01). Similarly, neovascularization scores were lower after PTB (0.8 ± 0.5 vs. 1.5 ± 0.6, P < 0.01). Quantification of MPO and CD31 levels from immunofluorecent staining indicated that PTB stimulated less neutrophil infiltration (5.3 ± 2.2 vs. 13.3 ± 3.1, P < 0.01) and less new blood vessels formation (2.0 ± 0.8 vs. 6.3 ± 1.3, P < 0.01) at the wound site. The collagen alignment in PTB-treated corneas, as shown by immunofluorescence and second harmonic generation image, was better organized in the PTB-treated group than in the suture group. CONCLUSION: Bonding LSC grafts with PTB produced improved outcomes compared to suture attachment. This light-activated method is a promising modality for treating patients with LSCD.
