[The diagnosis of microcirculatory-rheological disorders and their correction in patients with the initial manifestations of insufficiency of the cerebral blood supply]. / Diagnostika mikrotsirkuliatorno-reologicheskikh narushenii i ikh korrektsiia u bol'nykh s nachal'nymi proiavleniiami nedostatochnosti krovosnabzheniia mozga.

An evaluation was done of the state of bulbar microcirculation and aggregability of blood platelets in 47 patients presenting with early manifestations of cerebral circulatory insufficiency. A correlation was established between the revealed disturbances in the microcirculatory bed and augmentation of aggregational activity of thrombocytes. Computation of the integrative guide, microcirculatory-rheologic index, reflecting objectively the degree of intravascular hemocirculatory disorders has been performed. Treatment with calcium antagonist corinfar, antihypoxic agent actovegin was of particular benefit for the patients when administered in combination; more than half of the parameters characterizing microcirculation, rheologic properties of blood, microcirculatory-rheologic index have all returned to normal.

[Changes in the microcirculatory rheological properties of the blood and their correction in patients with atherosclerotic and involutional depressions]. / Izmeneniia mikrotsirkuliatorno-reologicheskikh svoistv krovi i ikh korrektsiia u bol'nykh ateroskleroticheskoi i involiutsionnoi depressiei.

The microcirculatory state (by the method of conjunctival biomicroscopy) and ADP-induced platelet aggregation were examined in 42 patients with atherosclerotic and 34 patients with involutional depression both before and after the treatment which included vasoactive preparations and calcium antagonists. It was determined vascular and intravascular alterations predominance and increase of platelet aggregation in patients with atherosclerotic depression independently of leading syndrome, in patients with involutional depression with anxiety prevalence as well as in patients in stuporous state. The tendency was revealed of such disturbances increasing as for as psychosis was extended. Trental and Cavinton antiplatelet and spasmolytic properties were potentiated by inclusion of Corinfar in complex therapy and that promoted earlier microcirculatory alterations removal as well as aggregatograms and patient mental state normalization.

[The correction of the metabolic and microcirculatory disorders in patients with atherosclerotic and involutional depressions]. / Korrektsiia metabolicheskikh i mikrotsirkuliatornykh narushenii u bol'nykh s ateroskleroticheskoi i involiutsionnoi depressiei.

A total of 42 patients with atherosclerotic--and 34 with involutional depression were studied by conjunctival biomicroscopy for particular features of lipid peroxidation and state of microcirculation before and after treatment with vasoactive preparations, antioxidants and calcium antagonists. POL were found to be increased in patients with atherosclerotic depression irrespective of the syndrome, and in involutional depression with anxious symptomatology, as well as in those patients in stuporous state, this being accounted by a decreased provision of the organism with antioxidants as well as by an inadequate activity of antioxidant enzymes; high incidence rate of intravascular and vascular changes was also noted in the above patient populations. Tocoferolum acetatum and corinfar potentiated antiaggregational and spasmolytic actions of vasoactive preparations, which fact made for an earlier eradication of microcirculatory disturbances, decrease in the free radical oxidation activity and recovery of those patients getting out of the psychotic state.

[The korinfar and actovegin treatment of patients with a chronic ischemic disorder of the cerebral circulation]. / Lechenie korinfarom i aktoveginom bol'nykh s khronicheskim ishemicheskim narusheniem krovosnabzheniia mozga.

A study is presented of 42 patients with different stages of dyscirculatory encephalopathy of atherosclerotic genesis who showed disorders of the cerebral hemodynamics, microcirculation, increase of the aggregational capacity of thrombocytes and activation of lipid peroxidation. The patients were treated with corinfar and actovegin and this resulted in normalization of the microcirculation and rheological properties of the blood. Corinfar also reduced activation of lipid peroxidation processes.

[The effect of combined treatment with the use of magnetotherapy on the systemic hemodynamics of patients with ischemic heart disease and spinal osteochondrosis]. / Vliianie kompleksnogo lecheniia s primeneiem magnitoterapii na sistemnuiu gemodinamiku u bol'nykh ishemicheskoi bolezn'iu serdtsa i osteokhondrozom pozvonochnika.

The authors examined 66 patients with ischemic heart disease and concomitant cervico-thoracic osteochondrosis and 22 patients without osteochondrosis. Differences were revealed in values of the systemic hemodynamics with prevalence of the hypokinetic type in patients with combined pathology. Inclusion of magnetotherapy in the treatment complex of patients with ischemic heart disease and osteochondrosis favours clinical improvement, normalization of indices of central and regional blood circulation.

[The significance of risk factors in the development of disorders of the cerebral venous circulation]. / Znachenie nekotorykh faktorov riska v razvitii rasstroistv venoznogo krovoobrashcheniia mozga.

The state of venous brain circulation in patients suffering of arterial hypertension, excessive weight, hyperlipidemia, ischemic heart disease was investigated using laboratory instrumental methods of examination (rheoencephalography, conjunctival biomicroscopy, determination of lipids in the blood serum and oth.). It was established that subjects with risk factors show often instability of the brain venous tone, while patients with initial signs of brain vessel insufficiency show signs of hypotension. These changes may not be clinically overt, have a compensatory character and diagnosis often requires instrumental methods of examination.

[The correction of microcirculatory disorders in patients with circulatory encephalopathy]. / Korrektsiia narushenii mikrotsirkuliatsii u bol'nykh s distsirkuliatornoiéntsefalopatiei.

The state of microcirculation was studied by bulbar biomicroscopy in 18 healthy persons and 53 patients with dyscirculatory encephalopathy before and after treatment with vasoactive drugs (xanthinol nicotinate, Cavinton, Sermion). It was found that the microcirculation changes depended on the stage of the disease. It was found that the above drugs produced a positive effect on the microcirculation, the values of which normalized by the end of the course of treatment, especially after their direct administration.

[Microcirculation and the blood rheological properties and their correction in ischemic disorders of the cerebral circulation]. / Mikrotsirkuliatsiia, reologicheskie svoistva krovi i ikh korrektsiia pri ishemicheskikh narusheniiakh mozgovogo krovoobrashcheniia.

A study was made of microcirculation using bulbar biomicroscopy and of the aggregation properties of platelets in 94 patients with initial manifestations of cerebral circulatory failure and dyscirculatory encephalopathy before and after the treatment with vasoactive drugs and actovegin. It has been recorded that the impairment of blood microcirculation progresses with the rise of the disease stage, being more pronounced in patients with vegetovascular crises. To correct microcirculatory disorders and the rheological properties of blood, the authors provide evidence for administering cavinton, euphylline and nicotinic acid combined with actovegin.

[Diagnosis and pathogenetic treatment of venous encephalopathy in early atherosclerosis]. / Diagnostika i patogeneticheskoe lechenie venoznoi éntsefalopatii pri rannem ateroskleroze.

The authors investigated the diagnosis and treatment of the initial forms of venous encephalopathy in atherosclerosis in 42 patients, using synchronous rheoencephalography and jugular rheophlebography under conditions of graded exercise on a bicycle ergometer. The study revealed signs of venous encephalopathy with dystonic, asthenovegetative, psychopathological, pseudotumorous and other syndromes which were confirmed by changes in the parameters of the REG, rheophlebogram, etc. Graded exercise in a compensated phase of the disease led to a reduction in signs of venous congestion in the brain, while in a subcompensated phase these signs increased. The effect of a multiple modality treatment with due regard to the phase of compensation and the leading syndrome was good or satisfactory in the majority of patients.