[Synthesis and acceptor properties of 11-[(9'-anthracenyl)methoxy]undecyl phosphate and P1-{11-[(9'-anthracenyl)methoxy]undecyl}-P2-(alpha-D-galactopyranosyl) diphosphate in the enzymic reactions catalyzed by galactosylphosphotransferase and mannosyltransferase from Salmonella newport].

Fluorescent 11-[(9'-anthracenyl)methoxy]undecyl phosphate and P1-{11-[(9'-anthracenyl)methoxy]undecyl}-P2-(alpha-D-galactopyranosyl) diphosphate were chemically synthesized for the first time. The ability of the first compound to serve as substrate-acceptor ofgalactosyl phosphate residue and the second compound of mannosyl residue in enzymic reactions catalyzed by galactosylphosphotransferase and mannosyltransferase from Salmonella newport membrane preparation was demonstrated.

[Synthesis of p(1)-(11-phenoxyundecyl)-P(2)-(alpha-D-galactopyranosyl) diphosphate and p(1)-(11-phenoxyundecyl)-P(2)-(alpha-D-glucopyranosyl) diphosphate; assay of their acceptor properties for mannosyl residue in the enzmic reaction catalyzed by mannosyltransferase from Salmonella newport].

P(1)-(Phenoxyundecyl)-P(2)-(alpha-D-galactopyranosyl) diphosphate as well as P(1)-(11-phenoxyundecyl)-P(2)-(alpha-D-glucopyranosyl) diphosphate are newly synthesized and their ability to serve as substrate-acceptor of mannosyl residue in enzymic reaction catalyzed by mannosyltransferase from Salmonella newport membrane preparation is investigated. The possibility ofgalactosyl-containing derivative to serve as mannosyl acceptor from GDP-Man is established whereas glucosyl-containing compound is inactive in this process.

[Simple synthesis of P¹-(11-phenoxyundecyl)-P²-(2-acetamido-2-deoxy-α-D-galactopyranosyl) diphosphate].

A simple scheme of synthesis of P¹-(11-phenoxyundecyl)-P²-(2-acetamido-2-deoxy-α-D-galactopyranosyl) diphosphate synthetic lipid acceptor for glycosyltransferases participating in gram-negative bacteria O-antigenic polysaccharides is suggested.

[Synthesis of 11-phenoxyundecyl phosphate and its use as an acceptor substrate in the reaction with UDP-GlcNAc : polyprenyl phosphate GlcNAc-phosphotransferase from Salmonella arizona O:59].

A new scheme of synthesis of 11-phenoxyundecyl phosphate from 11-bromoundecanoic acid was suggested for its ability to react as an acceptor of 2-acetamido-2-deoxy-alpha-D-glucopyranosyl phosphate in a reaction catalyzed by UDP-N-acetylglucosamine : polyprenyl phosphate N-acetylglucosamine phosphotransferase from Salmonella arizona O:59.

[A case of deletion of the short arm of the chromosome 21 (21p-) (christchurch chromosome) discovered prenatally:clinical and cytogenetic data]. / Opisanie sluchaia deletsii korotkogo plecha khromosomy 21 (21p-) (christchurch chromosome), vyiavlennogo prenatal'no: klinicheskie i tsitogeneticheskie dannye.

Results of cytogenetic research of placental villi and amniotic fluid cells culture of the 22-weeks-old fetus with multiple congenital malformations (MCM) are presented. The absence of the short arm in one of the homologue of the chromosome 21 was revealed. Cytogenetic analysis of the fetus father's blood lymphocytes determined the similar chromosome. Further research of the father's karyotype made by FISH-method using specific DNA samples had discovered the absence of subtelomeric parts in the short arm of the chromosome 21 that might be considered as a deletion. It was suggested that the effect of position and interaction of genes could play a key role in appearing of MCM in the fetus in the case when the 21p-chromosome was transferred to it from the healthy parents.

[Prolonged pharmacologic sleep in the complex treatment of patients with severe forms of alcoholic delirium]. / Prodlennyí medikamentoznyí son v komplekse lecheniia tiazhelykh form alkogol'nogo deliriia.

Results of treating 235 patients suffering from grave alcohol delirium complicated with somatic pathology are presented. Use was made of various methods of inducing prolonged drug sleep: by neuroleptics, barbiturates with analgesics sodium gamma-hydroxybutyrate alone or in combination with barbiturates or viadril. The method of using the combination of sodium gamma-hydroxybutyrate with barbiturates or viadril G appeared to be the most effective. It use resulted in a rapid elimination of psychomotor excitation, quick induction of deep sleep, considerable shortening of the psychotic period, rapid normalization of vitally important body functions, and shortening of the duration of the post-delirium asthenization.