An international comparison of HIV prevalence and incidence in blood donors and general population: a BEST Collaborative study.

BACKGROUND AND OBJECTIVES: Efficiency in mitigating HIV transmission risk by transfusion may vary internationally. We compared HIV prevalence and incidence in blood donors across different jurisdictions in relation to those rates in the general population and differences in deferral practices. MATERIALS AND METHODS: Data from 2007 to 2016 were collected in Australia, Brazil (São Paulo), Canada, England, France, Italy, Ireland, Japan, the Netherlands, New Zealand, Norway, Spain (Basque Country), USA (Vitalant) and Wales. For each country/region, the number of HIV antibody-positive donations and nucleic acid testing (NAT)-only-positive donations was broken down according to first-time or repeat donor status, along with the relevant denominators. RESULTS: There is a modest correlation between HIV prevalence among first-time donors and HIV prevalence in the general population. However, rates of HIV-positive donations in repeat donors, a proxy for incidence, do not correlate with incidence rates in the general population. Rates in donors from Italy and Basque Country, where deferral criteria for men having sex with men are less stringent, are higher compared with most other jurisdictions. Rates of NAT-only-positive donations are extremely low and do not differ significantly after adjustment for multiple comparisons. CONCLUSION: Donor HIV rates are only weakly associated with those observed in the general population. Countries with less stringent deferral criteria have higher HIV rates in their donor population, but the rates remain very low.

Frecuencia del déficit selectivo de IgA en el País Vasco / Frequency of selective IgA deficiency in Basque Country (Spain)

Fundamento: Conocer la prevalencia de déficit de IgA en el País Vasco y crear un registro de donantes IgA deficientes, mediante una técnica de laboratorio propia y la revisión de historias clínicas. Material y métodos: Se desarrolla un sistema de cribado de inmunodifusión radial sobre 2.607 muestras de donantes de sangre. Se realiza una búsqueda informática de resultados de laboratorio de pacientes ambulatorios y hospitalizados. Resultados: Se detectan 5 donantes IgA deficientes, y de 30 pacientes sólo dos cumplen criterios de donante. Conclusiones: La prevalencia de déficit de IgA en el País Vasco fue de 1/521. El método utilizado resulta óptimo y económico para la creación de un registro de donantes IgA deficientes (AU)