[Evaluation of the possibility of diagnosing purulent-septic rhinogenic complications of the orbit and eyelids in children based on the analysis of clinical and laboratory data]. / Otsenka vozmozhnosti diagnostiki gnoino-septicheskikh rinogennykh oslozhnenii orbity i vek u detei na osnove analiza kliniko-laboratornykh dannykh.

OBJECTIVE: To study the features of clinical and laboratory parameters of rhinogenic complications of the orbit (RCO) and eyelids depending on the blood leukocyte shift index (LSI) to create a predictive model in pediatric patients. MATERIAL AND METHODS: The study included 50 patients who were treated at the Regional Clinical Hospital No. 2 of Tyumen with inflammatory pathology of the paranasal sinuses. Group I with RCO - reactive edema of the eyelids and orbital tissue included 29 (58.0%) patients (of which 16 (32.0%) were boys, 13 (26.0%) were girls). In group 2 with ROC, purulent-septic complications of the eyelids and orbit included 21 (42.0%) patients (of which 10 (20.0%) were boys, 11 (22.0%) were girls). RESULTS: LSI values in the general age group (n=50) from 1 to 17 years old were: 1.61 [1.40; 1.82] in patients of group 1; 3.45 [2.96; 3.94] in patients of group 2 (p≤0.05). With an index of LSI from 1.36 to 1.96, the development of reactive edema of the eyelids and orbital tissue is predicted, from 3.14 to 4.72 - the development of purulent-septic complications of the eyelids and orbit in patients of preschool and primary school age. CONCLUSION: The marker of clinical and laboratory parameters of the severity of the disease is the LSI indicator, taking into account the age of the child, which can be used in the early diagnosis of purulent-septic rhinogenic complications of the orbit and eyelids in children.

[Membrane-active preparations as correctors of the nephrotoxicity of gentamicin]. / Membranoaktivnye preparaty kak korrektory nefrotoksichnosti gentamitsina.

At intracutaneous gentamicine injections in rats (dose 50 mg/kg) within 10 days the simultaneous application of anticalcium drugs makes nephrotoxic signs more pronounced; whereas antioxidants and essenciale make them less pronounced. Phospholipid complex, containing phosphatidylserin, sphingomyelin, and phosphatidylethanolamine does not exhibit a marked nephroprotective effect. The found character of changes in content of phosphoinozytols in urine indirectly confirms the role of disturbances of their metabolism in mechanism of aminoglycoside nephrotoxicity.