1.
Bioorg Khim
; 32(6): 643-50, 2006.
Article
in Russian
| MEDLINE
| ID: mdl-17180915
ABSTRACT
Convenient methods of synthesis of 1-aminooxy-3,8-diaza-11-aminoundecane, its earlier unknown N1-and N1 -acetyl derivatives, and also 1,10-bis(aminooxy)-3,8-diazadecane are suggested. It is shown a possibility to selectively delete the acid-labile ethoxyethylidene protection of aminooxy group by hydrosulfates in the presence of N-tert-butyloxycarbonyl group.
Subject(s)
Spermine/analogs & derivatives , Spermine/chemical synthesis
2.
Bioorg Khim
; 31(2): 206-12, 2005.
Article
in Russian
| MEDLINE
| ID: mdl-15889796
ABSTRACT
A new isosteric charge-deficient spermine analogue, 1,12-diamino-4,9-diaza-5-oxadodecan, and O-(7-amino-4-azaheptyl)oxime of 3-aminopropanal, a stable analogue of the Schiff base intermediate in the enzymatic oxidation of spermine, were synthesized. The possible use of these compounds for the inhibition of spermine oxidase is discussed.