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Article in English | MEDLINE | ID: mdl-20923955

ABSTRACT

OBJECTIVES: to determine the incidence and risk factors for nevirapine (NVP)-associated toxicity in a cohort of HIV-infected people in Buenos Aires, Argentina. DESIGN: retrospective study. METHODS: HIV-infected adults who received NVP-based highly active antiretroviral therapy (HAART) at least for 2 weeks between May 1997 and March 2008 were included in this study. We analyzed patients' age, gender, HIV transmission route, HIV disease stage, pregnancy, alcohol intake, adverse events, coinfection with hepatitis B or C virus, time until toxicity, and withdrawal rates. RESULTS: a total of 1110 patients (631 men) were included. Rash was the most frequently observed adverse event; it was more frequent in women. The incidence of severe rash and hepatotoxicity was similar in women and men. Female sex was the only variable significantly associated with mild-to-moderate rash. High CD4 count, pregnancy, and chronic hepatitis were not associated with NVP-related toxicity. An undetectable viral load at the time of starting NVP treatment resulted in a lower risk of NVP-related rash.


Subject(s)
Anti-HIV Agents/adverse effects , HIV Infections/drug therapy , Nevirapine/adverse effects , Adult , Argentina/epidemiology , CD4 Lymphocyte Count , Drug-Related Side Effects and Adverse Reactions/epidemiology , Female , Humans , Kaplan-Meier Estimate , Male , Multivariate Analysis , Pregnancy , Pregnancy Complications, Infectious/drug therapy , Pregnancy Complications, Infectious/virology , Proportional Hazards Models , Retrospective Studies , Risk Factors , Sex Distribution
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