ABSTRACT
Changes in lung elasticity as measured by the pressure-volume curve are used in clinical investigative studies to diagnose abnormalities in lung function and to evaluate changes in a patient either over time or with an acute intervention. To assess the intrinsic variability of parameters derived from this technique, 4 static deflation curves per day on 5 separate days during a 2-month period were constructed for 10 healthy adults. The pressure-volume data were fitted to the exponential equation: V = A-Be-KP. The coefficients of variation for maximal elastic recoil pressure, transpulmonary pressures at 90, 80, 70, and 60% total lung capacity, static expiratory compliance, and the constants A, B, and k were determined. No significant correlation was found between the variability of daily curves and that of curves performed on separate occasions. The natural log of the exponential constant showed the lowest coefficient of variation, indicating that this parameter is the most reproducible.
Subject(s)
Lung Volume Measurements , Lung/physiology , Adult , Elasticity , Female , Functional Residual Capacity , Humans , Lung Volume Measurements/methods , Male , Mathematics , Pressure , Time Factors , Total Lung Capacity/methodsABSTRACT
The principal licensed biologicals for human use in the United States have been listed with special emphasis given to antiviral vaccines. Possible adverse reactions of an immunologic nature which may be encountered in the use of these agents in routine immunization programs are described, while at the same time, their relative rarity is emphasized. The special problems one may encounter in immunizing the atopic child, the immunodeficient child, the child with active tuberculosis and the pregnant woman are considered separately, as are the undesirable consequences of hyperimmunization are mentioned.
