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Effect of Original Peptide Derivatives of Galantamine on Passive Avoidance in Mice.

Kostadinova, I I; Danchev, N D; Vezenkov, L T; Tsekova, D S; Rozhanets, V V.

Bull Exp Biol Med ; 170(2): 200-202, 2020 Dec.

Article in English | MEDLINE | ID: mdl-33269452

ABSTRACT

The effect of original peptide derivatives of galantamine on scopolamine-induced memory impairment in mice was assessed using the passive avoidance test over 12 days. It was found that some galantamine derivatives administered in a dose of 1/20LD50 improved the memory in experimental mice, especially on days 5-12 of the experiment.

Subject(s)

Avoidance Learning/drug effects , Galantamine/pharmacology , Peptides/pharmacology , Scopolamine/pharmacology , Alzheimer Disease/drug therapy , Animals , Behavior, Animal , Disease Models, Animal , Learning/drug effects , Male , Memory/drug effects , Memory Disorders/drug therapy , Mice , Peptides/chemistry

ABSTRACT

Subject(s)

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