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Int J Colorectal Dis ; 38(1): 107, 2023 Apr 21.
Article in English | MEDLINE | ID: mdl-37081187

ABSTRACT

PURPOSE: If could be a potential pathophysiological connection between colonic diverticula and colonic superficial neoplastic lesions, beyond the shared risk factors, has been a subject of debate in the last years. This study tries to evaluate the association between diverticulosis and colonic neoplastic lesions. METHODS: This is a cross-sectional study including asymptomatic patients who underwent a screening colonoscopy (patients with a positive fecal occult blood test under the regional program of colorectal cancer (CRC) screening), surveillance after polypectomy resection, or familiarity (first-degree relatives) between 2020 and 2021 to evaluate the association between diverticula and colonic polyps. A multivariate analysis with multiple logistic regression and odds ratio (OR) to study the independent association between adenomas and adenocarcinomas was performed. RESULTS: One thousand five hundred one patients were included. A statistically significant association between adenomas or CRC alone and colonic diverticula was found (p = 0.045). On a multivariate analysis of demographic (age, gender) and clinical parameters (familiarity for diverticula and adenoma/CRC), only age was significantly associated with the development of colorectal adenomas or cancer (OR 1.05, 95% CI 1.03-1.07, p < 0.0001). CONCLUSIONS: This study showed a statistically significant association between diverticula and colonic adenomas. However, it is impossible to establish a cause-effect relationship due to the intrinsic characteristics of this study design. A study with a prospective design including both patients with diverticulosis and without colonic diverticula aimed at establishing the incidence of adenoma and CRC could help to answer this relevant clinical question, since a potential association could indicate the need for closer endoscopic surveillance.


Subject(s)
Adenoma , Colonic Polyps , Colorectal Neoplasms , Diverticulosis, Colonic , Diverticulum, Colon , Humans , Diverticulum, Colon/complications , Cross-Sectional Studies , Colonoscopy/adverse effects , Colonic Polyps/pathology , Colorectal Neoplasms/pathology , Diverticulosis, Colonic/complications , Diverticulosis, Colonic/diagnosis , Diverticulosis, Colonic/epidemiology , Risk Factors , Adenoma/diagnosis
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