ABSTRACT
A complex organometric, stereohistometric and immunomorphological investigation of thyroid gland of intranatally decreased mature fetuses from women with hyperthyroidesm is performed. Parallel study of thyroid hormones levels in a cord blood and thyroid status of woman in childbirth, on the one hand, and study of morphological peculiar properties and morphometric parameters of fetal thyroid gland, on the hand, allows us to obtain a clear idea on morphological insufficiency of their thyroid gland on the eve of beginning of their extrauterine life. It also throws some light on some pathogenic elements of disfunctions of thyroid status in the newborn of women with hyperthyroidism.
Subject(s)
Fetal Death , Hyperthyroidism , Thyroid Gland/embryology , Thyroid Gland/physiology , Female , Fetal Blood , Gestational Age , Humans , Maternal-Fetal Exchange , Pregnancy , Thyroglobulin/blood , Thyroid Gland/pathology , Thyrotropin/blood , Thyroxine/blood , Thyroxine-Binding Proteins/metabolism , Triiodothyronine/bloodABSTRACT
Hyperthyroidosis in pregnancy (16 cases) severely alters positive and negative correlations between maternal and neonatal thyroid hormones, as well as the morphofunctional state of the placenta. Chronic placenta failure (degrees I-II) and activation of the structures responsible for additional synthesis of placental lactogen results in transplacental passage of thyroxin to the fetus and newborn.
Subject(s)
Hyperthyroidism/pathology , Placenta/pathology , Pregnancy Complications/pathology , Thyroid Hormones/blood , Female , Fetal Blood , Humans , Hyperthyroidism/blood , Infant, Newborn , Maternal-Fetal Exchange , Pregnancy , Pregnancy Complications/bloodSubject(s)
Bone Neoplasms/pathology , Sarcoma, Ewing/pathology , Tibia/pathology , Child , Diagnosis, Differential , Female , HumansABSTRACT
67 brain tumors were studied using monoclonal antibodies against glial fibrillary acid protein (GFAP), neurofilaments, proteoglycan, laminin and vimentin. All the astrocytic tumors gave positive reaction to GFAP, but anaplastic tumors of this type were less reactive. Medulloblastomas when treated with GFAP showed two cell lines, astrocytic and neuronal. A positive reaction to laminin and proteoglycan was observed in the vessels of neuroepithelial tumors. Anaplastic astrocytomas were more reactive to vimentin.