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Ann Pathol ; 31(5): 341-4, 2011 Oct.
Article in French | MEDLINE | ID: mdl-21982239

ABSTRACT

Vulvar Paget's disease is sub-classified into three types based upon its origin. It might be a primary vulvar disease (type 1) or associated with a non-cutaneous adenocarcinoma-rectal, colonic, cervical (type 2) or linked with an urothelial neoplasia (type 3). Type 1lesions must be considered as potentially invasive. Their immunophenotype is CK7+/CK20-. Classically, in case of depth of invasion below 1mm, nodal metastases are exceptional. We report a case of type 1 Paget's disease in a postmenopausal woman with superficial invasion and multiple inguinal nodal metastases.


Subject(s)
Lymphatic Metastasis , Paget Disease, Extramammary/pathology , Vulvar Neoplasms/pathology , Aged , Biomarkers, Tumor/analysis , Female , Frontal Lobe , Humans , Keratins/analysis , Meningeal Neoplasms , Meningioma , Neoplasm Invasiveness , Neoplasms, Second Primary , Paget Disease, Extramammary/chemistry , Paget Disease, Extramammary/secondary , Peptidyl-Dipeptidase A/analysis , Postmenopause , Receptor, ErbB-2/analysis , Receptors, Estrogen/analysis , Vulvar Neoplasms/chemistry
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