ABSTRACT
Menopause causes important bodily and metabolic changes, which favor the increased occurrence of cardiovascular diseases, obesity, diabetes, and osteoporosis. Resveratrol exerts proven effects on body metabolism, improving glucose and lipid homeostasis and reducing inflammation and oxidative stress in various organs and tissues. Accordingly, this study evaluates the effects of resveratrol supplementation on the expression of markers associated with thermogenesis in brown adipose tissue, and on the body, metabolic and hormonal parameters of female mice submitted to bilateral oophorectomy. Eighteen female mice were randomized into three groups: G1: control (CONTROL), G2: oophorectomy (OOF), and G3: oophorectomy + resveratrol (OOF + RSV); the animals were kept under treatment for twelve weeks, being fed a standard diet and treated with resveratrol via gavage. Body, biochemical, hormonal, and histological parameters were measured; in addition to the expression of markers associated with thermogenesis in brown adipose tissue. The results showed that animals supplemented with resveratrol showed reduced body weight and visceral adiposity, in addition to glucose, total cholesterol, and triglyceride levels; decreased serum FSH levels and increased estrogen levels were observed compared to the OOF group and mRNA expression of PRDM16, UCP1, and SIRT3 in brown adipose tissue. The findings of this study suggest the important role of resveratrol in terms of improving body, metabolic, and hormonal parameters, as well as modulating markers associated with thermogenesis in brown adipose tissue of female mice submitted to oophorectomy.
Subject(s)
Adipose Tissue, Brown , Dietary Supplements , Ovariectomy , Resveratrol , Thermogenesis , Uncoupling Protein 1 , Animals , Resveratrol/pharmacology , Resveratrol/administration & dosage , Female , Thermogenesis/drug effects , Thermogenesis/genetics , Mice , Adipose Tissue, Brown/metabolism , Adipose Tissue, Brown/drug effects , Uncoupling Protein 1/genetics , Uncoupling Protein 1/metabolism , Administration, Oral , Gene Expression Regulation/drug effects , Transcription Factors/genetics , Transcription Factors/metabolism , DNA-Binding Proteins/genetics , DNA-Binding Proteins/metabolism , Sirtuin 3/genetics , Sirtuin 3/metabolism , Body Weight/drug effects , Hormones/bloodABSTRACT
Introduction Cephalgia or cephalalgia is one of the most common symptoms in the general population. Objective To compare the efficacy of physical therapy modalities, through manual therapy and the effect of Transcutaneous Nerve Stimulation (TENS) for tension-type cephalalgia. Materials and methods The study was compounded by 60 subjects, but only 40 of them completed it, due to the exclusion criteria. These were divided into control group and intervention group. The control group received treatment — manual therapy. The intervention group received TENS Burst. Patients underwent ten sessions of treatment, made at every two days on a week, lasting 30 minutes each session. Results The characteristics related to lifestyle, postural issues and range of motion are responsible for the main causes of tension-type cephalalgia. Discussion treatments showed effective results in all cases in relation to pain intensity, but the use of manual therapy techniques give the patient a better quality of life compared to the use of TENS. Final considerations The treatment of this condition deserves analysis and studies; however, there are only a few studying physical therapy techniques, especially regarding to the use of TENS. .
Introdução Cefaleia ou dor de cabeça é um dos sintomas mais comuns na população em geral. Objetivo Comparar a eficácia de modalidades de fisioterapia — terapia manual e estimulação nervosa transcutânea (TENS) — para cefaleia do tipo tensional. Materiais e métodos O estudo foi composto inicialmente por 60 indivíduos, mas apenas 40 completaram-no em virtude dos critérios de exclusão. Estes foram divididos em grupo controle e grupo de intervenção. O grupo controle recebeu terapia manual e o grupo de intervenção recebeu TENS. Os pacientes foram submetidos a 10 sessões de tratamento, sendo estas feitas dois dias por semana, com duração de 30 minutos cada. Resultados As características relacionadas ao estilo de vida, problemas posturais e amplitude de movimento são responsáveis pelas principais causas de dor de cabeça de tensão. Discussão Os tratamentos foram eficazes em todos os casos em relação à intensidade de dor, mas a utilização de técnicas de terapia manual deu aos pacientes uma melhor qualidade de vida, em comparação com a utilização de TENS. Considerações finais O tratamento dessa condição merece análise e estudos, no entanto, há poucos estudos científicos que estudam técnicas de fisioterapia, especialmente com relação ao uso da TENS. .
