ABSTRACT
Estrogen receptors were measured in normal canine lymph nodes and neoplastic tissue from dogs with lymphoma, using a commercially available [3H]estradiol dextran-coated charcoal assay. Using the same assay, estrogen receptors were detected in the positive-control tissues--dog uterus, rat uterus, and lyophilized bovine uterus. Specific binding of [3H]estradiol was not detected in rat skeletal muscle or in any of the canine lymphoid tissues, indicating that the specimens did not contain estrogen receptors.
Subject(s)
Dog Diseases/metabolism , Lymph Nodes/chemistry , Lymphoma/veterinary , Receptors, Estrogen/analysis , Animals , Biopsy/veterinary , Cattle , Cytosol/chemistry , Dogs , Female , Lymphoma/chemistry , Male , Rats , Rats, Inbred Strains , Uterus/chemistryABSTRACT
Saphenous nerve biopsy was performed to diagnose globoid cell leukodystrophy in a 3-month-old West Highland White Terrier. The dog had progressive neurologic disease that appeared to involve the cerebellum, spinal cord, and lower motor neurons to the hind limbs. Light and transmission electron microscopic findings of the nerve biopsy specimen established the diagnosis. Peripheral nerve biopsy may provide a reliable antemortem method for diagnosis of globoid cell leukodystrophy.
Subject(s)
Dog Diseases/diagnosis , Leukodystrophy, Globoid Cell/veterinary , Peripheral Nerves/pathology , Animals , Biopsy/veterinary , Diagnosis, Differential , Dog Diseases/genetics , Dog Diseases/pathology , Dogs , Female , Leukodystrophy, Globoid Cell/diagnosis , Leukodystrophy, Globoid Cell/genetics , Leukodystrophy, Globoid Cell/pathology , Microscopy, Electron , Peripheral Nerves/ultrastructureSubject(s)
Brain Neoplasms/veterinary , Dog Diseases/pathology , Dysgerminoma/veterinary , Eye Neoplasms/veterinary , Testicular Neoplasms/veterinary , Animals , Brain Neoplasms/pathology , Brain Neoplasms/secondary , Dogs , Dysgerminoma/pathology , Dysgerminoma/secondary , Eye Neoplasms/pathology , Eye Neoplasms/secondary , Male , Testicular Neoplasms/pathologyABSTRACT
A cardiac fibrosarcoma involving the right ventricular free wall, the interatrial septum, and proximal portion of the interventricular septum, with a 2-cm diameter protrusion into the right atrial lumen, was found at necropsy of a 2-year-old Miniature Schnauzer. Severe distortion of the tricuspid valve and narrowing of the aortic and pulmonic outflow tracts had caused the dog to develop right-sided cardiac failure and to have syncopal episodes. A tentative antemortem diagnosis of congenital pulmonic stenosis had been made on the basis of results of physical examination and diagnostic work-up. Evaluation of the case exemplifies the difficulty encountered in diagnosing cardiac tumors before the patient's death.
