Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 10 de 10
Filter
1.
Nutrition ; 16(2): 87-90, 2000 Feb.
Article in English | MEDLINE | ID: mdl-10696629

ABSTRACT

Fish oil omega-3 fatty acids exert antiinflammatory effects on patients with ulcerative colitis. However, a comparative study in patients with mild to moderate ulcerative colitis receiving only sulfasalazine or omega-3 fatty acids has not been performed. We sought to detect changes in the inflammatory disease activity with the use of either fish oil omega-3 fatty acids or sulfasalazine in patients with ulcerative colitis. Ten patients (five male, five female; mean age = 48 +/- 12 y) with mild to moderate active ulcerative colitis were investigated in a randomized cross-over design. They received either sulfasalazine (2 g/d) or omega-3 fatty acids (5.4 g/d) for 2 m.o. Disease activity was assessed by clinical and laboratory indicators, sigmoidoscopy, histology, and whole-body protein turnover (with 15N-glycine). Treatment with omega-3 fatty acids resulted in greater disease activity as detected by a significant increase in platelet count, erythrocyte sedimentation rate, C-reactive protein, and total fecal nitrogen excretion. No major changes in protein synthesis and breakdown were observed during either treatment. In conclusion, treatment with sulfasalazine is superior to treatment with omega-3 fatty acids in patients with mild to moderate active ulcerative colitis.


Subject(s)
Colitis, Ulcerative/drug therapy , Fatty Acids, Omega-3/therapeutic use , Sulfasalazine/therapeutic use , Adult , Aged , Biopsy , Blood Sedimentation , C-Reactive Protein/analysis , Colitis, Ulcerative/pathology , Colitis, Ulcerative/physiopathology , Colon/pathology , Female , Fish Oils/therapeutic use , Humans , Male , Middle Aged , Platelet Count , Proteins/metabolism , Sigmoidoscopy
3.
Arq Gastroenterol ; 35(3): 175-80, 1998.
Article in Portuguese | MEDLINE | ID: mdl-10029862

ABSTRACT

Disease activity was assessed in 10 (five males and five females) ulcerative colitis patients through the following parameters: clinical, laboratory, sigmoidoscopic and histological. Protein metabolism was also assessed with 15N-glycine and urinary ammonia as end product. Only one patient had exacerbation of the disease two months after the study started. This patient presented in the beginning of the study protein synthesis and breakdown of 4.51 and 3.47 g protein/kg/day, respectively, values higher than all other patients, showing an hypermetabolic state, suggesting an increase of the disease activity. However, this increase was not detected by others indicators and indexes utilized. These data allow to suggest the hypothesis that protein metabolism predicts precociously the exacerbation of disease activity in ulcerative colitis patients.


Subject(s)
Colitis, Ulcerative/diagnosis , Proteins/metabolism , Colitis, Ulcerative/metabolism , Female , Glycine/metabolism , Humans , Male , Middle Aged , Severity of Illness Index
4.
Arq Gastroenterol ; 34(1): 13-21, 1997.
Article in Portuguese | MEDLINE | ID: mdl-9458955

ABSTRACT

The effects of the clinical and dietetics in patient managements on the protein-energy status of hospitalized patients were retrospectively (four yr) investigated in 243 adult (49 +/- 16 yr), male (168) and female (75) patients suffering from chronic liver diseases (42%), intestinal diseases with diarrhea (14%), digestive cancers (11%), chronic pancreatitis (10%), stomach and duodenum diseases (7%), acute pancreatitis (7%), primary protein-energy malnutrition (3%), esophagus diseases (3%), intestinal diseases with constipation 14 (2%) and chronic alcoholism (2%). The protein-energy nutritional status assessed by combinations of anthropometric and blood parameters showed 75% of protein energy malnutrition at the hospital entry mostly (4/5) in severe and moderate grades. The overall average of hospitalization was 20 +/- 15 days being the shortest (13 +/- 5,7 days) for esophagus diseases and the longest (28 +/- 21 days) for the intestinal diseases with diarrhea patients which also received mostly (42%) of the enteral and/or parenteral feedings followed by acute pacreatitis (41%) and digestive cancers (31%) patients. When compared to the entry the protein-energy malnutrition rate at the discharge decreased only 5% despite the increasing of 30% found on the protein-energy intake. The main improvement of the protein-energy nutritional status were attained to those patients showing protein-energy malnutrition milder degrees at the entry which belonged mostly to primary protein-energy malnutrition, acute pancreatitis and intestinal diseases with diarrhea diseases. The later two groups showed protein-energy nutritional status improvement only after the second week of hospitalization. The digestive cancers patients had their protein-energy nutritional status worsened throughout the hospitalization whereas it happened only in the first week for the intestinal diseases with diarrhea and chronic liver diseases patients, improving thereafter up to the discharge. The protein-energy nutritional status improvement found in few patients could be attributed to some complementary factors such as theirs mild degree of protein-energy malnutrition at entry and/or non-invasive propedeutics and/or enteral-parenteral feddings and/or longer hospitalization staying. The institutional causes for the unexpected lack of nutritional responses by the patients were probably the high demand for the few available beds which favour the hospitalization of the most severed patients and the university-teaching pressure for the high rotation of the available beds. Both often resulting in early discharging. In persisting the current physical area and attendance demand one could suggest an aggressive support early at the entry preceding and/or accompanying the more invasive propedeutical procedures.


Subject(s)
Gastrointestinal Diseases , Hospitalization , Inpatients , Nutritional Status , Protein-Energy Malnutrition , Adult , Energy Intake , Female , Humans , Male , Middle Aged , Nutrition Assessment , Nutritional Support , Prevalence , Protein-Energy Malnutrition/epidemiology , Retrospective Studies
5.
Arq Gastroenterol ; 32(4): 172-7, 1995.
Article in Portuguese | MEDLINE | ID: mdl-8734853

ABSTRACT

The case of a patient with ulcerative colitis and isolated sacro-ileitis is presented. She suffered reactivation of the intestinal disease with diclofenac. The patient was allergic to sulfasalazine and was using fish oil fatty acid. The possible mechanisms of reactivation of the inflammatory bowel disease with non-steroidal anti-inflammatory drugs are discussed. It is suggested when necessary the utilization of non-steroidal anti-inflammatory drugs that inhibits the lipoxygenase in these patients.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Colitis, Ulcerative/drug therapy , Colitis, Ulcerative/complications , Colitis, Ulcerative/diagnosis , Diclofenac/adverse effects , Diclofenac/therapeutic use , Fatty Acids, Unsaturated/administration & dosage , Female , Humans , Ileitis/complications , Middle Aged
6.
Arq Gastroenterol ; 31(1): 18-23, 1994.
Article in Portuguese | MEDLINE | ID: mdl-8085950

ABSTRACT

The active electrogenic absorption of glucose was studied in 12 niacin deficient rats using a method for measuring changes in transmural potential difference across jejunal mucosa. The glucose was infused in 6 different concentrations (2.5; 5.0; 10.0; 20.0; 50.0 and 100.0 mM/L) at a constant rate of 1.7 ml per minute. The apparent kinetic parameters (Km and Pdmax) of active electrogenic transport were obtained graphically from curves of glucose transfer potentials. The results were compared with that obtained in a control group. The curve of glucose transfer potential in niacin deficient group was significantly lower than that of the control group. The apparent Km of niacin deficient group was greater than in the control group (16.1 x 12.7 mM/L). Furthermore, the Pdmax of the deficient group was lower than that of the control group (12.5 x 19.4 mV). The results showed that in niacin deficiency occurs a decreasing of the active electrogenic glucose absorption. One of the possible interpretation of the differences in the kinetic characteristics of electrogenic glucose transport would be a depleted energy supplement for the active transport in the enterocyte of the niacin deficient rats.


Subject(s)
Glucose/pharmacokinetics , Jejunum/metabolism , Niacin/deficiency , Animals , Biological Transport, Active , Intestinal Absorption , Male , Niacinamide/analogs & derivatives , Niacinamide/urine , Rats , Rats, Wistar
7.
Arq Gastroenterol ; 28(3): 86-92, 1991.
Article in Portuguese | MEDLINE | ID: mdl-1843243

ABSTRACT

The nutritional assessment by 24 hour-dietary recall, anthropometry and blood-components measurements was undertaken in 23 adult patients, 17 males and 6 females suffering of chronic diarrhea from pancreatitis (30%), inflammatory bowel disease (22%), short intestine syndrome (9%) and unknown diarrhea (35%). The nutritional assessment was done at the entry and repeated at the discharge of the hospitalization that averaged 35 days, during which the patients received specific medical treatment along with obstipating diets. The hospitalization resulted in overall improvement of the patients either clinically by reducing their defecation rate or nutritionally by increasing their protein-energy intake and the values of anthropometry and blood components (albumin, free-tryptophan and lymphocytes). When the patients where divided into two groups based on their fecal-fat output one could note the better nutritional response of the group showing steatorrhea than the non-steatorrhea group, with the serum albumin and the arm-muscle circumference being discriminatory between groups. However even in the better recovered patients the indicative values of a satisfactory nutritional status were not accomplished. Thus, these data suggest that besides the overall nutritional improvement seen in the studied chronic diarrhea patients the full-nutrition recovering would demand either or both a longer hospitalization and/or an early-aggressive nutritional support.


Subject(s)
Diarrhea/diet therapy , Nutrition Disorders/diet therapy , Nutritional Status , Adult , Chronic Disease , Diarrhea/drug therapy , Diarrhea/etiology , Energy Intake , Female , Humans , Inflammatory Bowel Diseases/complications , Male , Middle Aged , Nutrition Assessment , Nutrition Disorders/etiology , Pancreatitis/complications , Short Bowel Syndrome/complications
8.
Arq Gastroenterol ; 27(4): 191-6, 1990.
Article in Portuguese | MEDLINE | ID: mdl-2133194

ABSTRACT

The kinetic of jejunal glucose transport was studied using perfused rat jejunum in vivo. Ninety rats were fed a diet deficient in niacin and 90 a control diet. The jejunal loops of 7 groups of animal were infused each group with one of following solutions of glucose: 5, 10, 20, 40, 80, 160 and 300 mM/l. The Vmax and Km values were determined. The results showed that the vitamin-deficient rats absorbed less glucose independently of the amount infused and these animals had lower Vmax (133.7 microM/15 min/15 cm) and Km (192.1 mM/l) than control groups (294.1 microM/15 min/15 cm and 171.8 mM/l, respectively). In conclusion one can assume that niacin deficiency leads to a decreased glucose absorption in the jejunal loops, when tested as in our experimental model.


Subject(s)
Glucose/pharmacokinetics , Jejunum/metabolism , Niacin/deficiency , Animals , Intestinal Absorption/drug effects , Male , Perfusion , Rats , Rats, Inbred Strains
9.
Arq Gastroenterol ; 27(2): 62-6, 1990.
Article in Portuguese | MEDLINE | ID: mdl-2094184

ABSTRACT

The effect of dietary-induced niacin deficiency on intestinal absorption of fat and nitrogen was studied in 18 rats through the metabolic balance technique. When compared with de control group (n = 9) the niacin deficient rats (n = 9) showed higher fecal fat and nitrogen output. The former was diarrhea-dependent and the later diarrhea independent processes. It is suggested that niacin deficiency might induced an early impairment in the intestinal protein absorption followed by diarrhea which would account lately for the fat malabsorption.


Subject(s)
Dietary Fats/metabolism , Intestinal Absorption , Niacin/deficiency , Nitrogen/metabolism , Animals , Body Weight , Diet , Dietary Fats/analysis , Feces/chemistry , Male , Rats , Rats, Inbred Strains
10.
Arq Gastroenterol ; 26(4): 111-5, 1989.
Article in Portuguese | MEDLINE | ID: mdl-2486029

ABSTRACT

In niacin deficient rats, it was performed a kinetic and morphometric study of jejunal epithelium. It was observed that the deficient animals showed less villosity (515.1 mu x 570.1 mu; p less than 0.008), enterocyte (35.3 mu x 38.5 mu; p less than 0.004) and mitotic index (4.4% x 5.7%; p less than 0.001) and bigger crypt (238.0 mu x 186.1 mu; p less than 0.001) and cellular renovation time (22.9h x 17.8h; less than 0.001) according to control animals. It is suggested that NAD (nicotinamide-adenine dinucleotide) deficiency can be responsible for the observed alterations.


Subject(s)
Diet , Jejunum/pathology , Niacin/deficiency , Animals , Body Weight , Epithelium/pathology , Male , Microtomy , Mitotic Index , Rats , Rats, Inbred Strains
SELECTION OF CITATIONS
SEARCH DETAIL
...